原发性肝癌MnDPDP增强MRI四种GRE序列的比较研究  

Comparative study of four GRE sequences in MnDPDP-enhanced magnetic resonance imag-ing for primary hepatocellular carcinoma

作　　者：郭涛[1] 张雪林[1] 昌仁民[1] 张玉忠[1] 

机构地区：[1]第一军医大学南方医院影像中心,广东广州510515

出　　处：《第一军医大学学报》2003年第9期946-948,共3页Journal of First Military Medical University

摘　　要：目的评价4种GRE序列在原发性肝癌锰福地吡三钠(MnDPDP)增强MRI检查中的价值。方法对13例原发性肝癌患者进行常规平扫和MnDPDP增强扫描。平扫序列为T1W FLASH、压脂FLASH、同相位与反相位FLASH,以及T2W TSE,静脉滴注MnDPDP后30 min开始增强扫描,并进行24 h延迟成像,采用与平扫相同的T1W序列。计算肝脏及病灶信噪比(SNR)及病灶与肝脏的对比噪声比(CNR)。结果4种GRE序列成像SNR和CNR无显著性差异(P>0.05),但反相位能检出常规FLASH和同相位无法显示的肝癌脂肪变性。结论同反相位序列可反映肝癌脂肪变性特征,检查简便,在对肝癌患者进行MnDPDP增强MRI检查时建议常规采用。Objective To assess the value of four T 1 -weighted (T 1 W) gradient-recalled-echo (GRE) sequences in MnDPDP-en-hanced magnetic resonance imaging (MRI) for diagnosing primary hepatocellular carcinoma (HCC). Methods T 1 W images of fast low-angle shot (FLASH), fat-suppressed (FS) FLASH, in-phase and opposed-phase (IP/OP) FLASH were obtained from 13 HCC patients before and 30 min after the patients were given 5 μmol/kg·b.w. MnDPDP. The delayed (24 h) images were also obtained with the same sequences in addition to the T 2 W turbo spin-echo (TSE) sequence performed before MnDPDP ad-ministration. The signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) of the liver parenchyma and the tumor foci were calculated for each sequence. Results No statistical differences were found in SNR and CNR between the images ob-tained with the four T 1 W sequences (P>0.05). The fatty degeneration of HCC could be detected by OP imaging, but not by T 1 W FLASH or IP T 1 W imaging. Conclusion IP and OP FLASH produces better and easier performance in characterizing the fatty degeneration of HCC, and are recommended for MnDPDP-enhanced MRI of HCC.

关 键 词：原发性肝癌 MNDPDP MRI GRE序列 锰福地吡三钠 成像序列 诊断 

分 类 号：R735.7[医药卫生—肿瘤] R730.44[医药卫生—临床医学]