上皮型钙粘附蛋白在子宫内膜癌中的表达及意义  

Expression of E-cadherin in endometrial carcinoma and its significance.

作　　者：方静[1] 刘惠喜[1] 李颖 高艳萍[1] 

机构地区：[1]西安交通大学第一医院妇产科,陕西西安710061 [2]西安军工医院,陕西西安710077

出　　处：《现代肿瘤医学》2003年第4期249-250,共2页Journal of Modern Oncology

摘　　要：目的　探讨上皮型钙粘附蛋白 (E -cad)在正常子宫内膜、子宫内膜不典型增生、子宫内膜癌中的表达 ,及其与临床参数间的关系。方法　应用免疫组化S -P法检测 14例正常子宫内膜、10例子宫内膜不典型增生及 5 0例子宫内膜癌中E -cad表达情况。结果　在正常子宫内膜、子宫内膜不典型增生及子宫内膜癌中 ,E -cad阳性表达率分别为 10 0 %、80 0 %、42 0 %,各组差异具有显著性 (P <0 .0 5 )。在G1、G2 、G3 子宫内膜癌中 ,E -cad阳性表达率分别为 72 2 %、30 0 %、16 7%(P <0 .0 5 )。在限于内膜组、浸润浅肌层及浸润深肌层组 ,E -cad阳性表达率分别为 6 8 4 %、35 3%、14 3%(P <0 .0 5 ) ,在临床Ⅰ、Ⅱ、Ⅲ期 ,E -cad阳性表达率分别为 6 0 9%、31 3%、18 2 %(P <0 .0 5 )。结论　E -cad异常表达与子宫内膜癌的发生发展密切相关。Objective To explore the expression of E-cadherin(E-cad)in normal endometrium,atypical hyperplasia and endometrial carcinoma.To study the relationship between the expression of E-cad clinical parameter.Methods The expression of E-cad was measured by immunohistochemical S-P method in 14 cases of normal endometrium,10cases of atypical hyperplasia and 50 cases of endometrial carcinoma.Results In normal endometrium,atypical hyperplasia and end ometrial carcinoma,the positive rates of E-cad were 100%,80.0%,42.0% respectively.The expression of E-cad has significantlly statistically difference among the three groups(P<0.05),I,G 1,G 2andG 3 endometrial carcinoma,the positive rates of E-cad were 72.2%,30.0%,16.7%respectively(P<0.05).In the lesion that limited to the endometrium group,superficial myometrial invasion group and deep myometrial invasion group,the positive rates of E-cad were68.4%,35.3%,14.3% respectively(P<0.05).In clinical stage Ⅰ,Ⅱ,Ⅲ,the positive rates of E-cad were 60.9% ,31.3%,18.2% respectively(P<0.05).Conclusion Aberrant expression of E-cad is closed related to the genesis and development of endometrial carcinoma.

关 键 词：上皮型钙粘附蛋白 子宫内膜癌 表达 免疫组织化学 

分 类 号：R737.33[医药卫生—肿瘤]