四川省恶性淋巴瘤发病与环境因素的病例对照研究  

A case-control study for assessing the relation between the inciden ce of malignant lymphomas and environmental factors in Sichuan province

作　　者：徐才刚[1] 郑素萍[1] 黄杰[1] 吴谨绪[1] 

机构地区：[1]四川大学华西医院临床流行病学教研室,血液科,成都610041

出　　处：《中华流行病学杂志》2003年第10期875-878,共4页Chinese Journal of Epidemiology

基　　金：国际临床流行病学网(INCLEN );美国洛氏基金资助项目

摘　　要：目的　探讨职业、环境因素、某些药物、社会经济及生活行为因素与淋巴瘤发病的相关性。方法　采用 1∶2配对病例对照研究 ,恶性淋巴瘤 150例 (病例组 ) ,非肿瘤病例 3 0 0例 (对照组 ) ,结果用logistic回归分析。结果　 ( 1)接触有机溶剂 ,如苯 [调整OR(aOR) =2 .78,P =0 .0 0 1]、香蕉水 (aOR =2 .2 8,P =0 .0 43 )、油漆 (aOR =1.96,P =0 .0 2 3 )和接触农药 ,包括有机磷类 (aOR =1.98,P =0 .0 3 4 )、菊酯类 (aOR =2 .57,P =0 .0 13 )以及有机氮类 (aOR =2 .55,P =0 .0 0 3 )会增加淋巴瘤发病的危险性。 ( 2 )经常使用一些药物 ,如阿斯匹林 (aOR =2 .3 6,P =0 .0 0 5)会使淋巴瘤发病的危险性增加。 ( 3 )饲养宠物狗 (aOR =1.76,P =0 .0 3 4 )与淋巴瘤发病的危险性增加有一定关系。 ( 4 )定期接受小剂量X线照射 (aOR =0 .49,P =0 .0 15)、经常患感冒 (aOR =0 .67,P =0 .0 2 4)则可能降低淋巴瘤发病的危险性。 ( 5)职业 (P >0 .0 5)、吸烟 (OR =1.0 1,P =0 .897)、戒烟 (OR =1.17,P =0 .0 73 )、饮酒 (aOR =1.2 6,P =0 .414 )、染发 (OR =1.0 6,P =0 .850 )、烫发 (OR =1.2 6,P =0 .43 8)、经济状况(OR =1.0 0 ,P =1.0 0 0 )和内向性格 (OR =1.2 6,P =0 .2 66)与淋巴瘤发病无明显相关性。结论　接触有?Objective To evaluate the relationships o f malignant lymphoma (ML) and exposure factors, including environmental,drug using ,socioeconomic level and life style etc. Methods (1) Hospital-based case-control study with 1 ∶2 matching was used; (2) 150 cases of ML and 300 controls were resulted; (3) logistic regression was used. Results (1) Adjust odds ratios (aOR) regarding contac t to organic solvents were:benzene aOR= 2.78 , P= 0.001 ;ba nana oil aOR= 2.28 , P= 0.043 ; paint aOR= 1.96 , P= 0.023 ;(2) aOR on pesticides contact:organic phosphorus a OR= 1.98 , P= 0.034 ; chrysanthester aOR= 2.57 , P= 0.013 ; organic nitride aOR= 2.55 , P= 0.003 ; (3) aOR of using aspirin was 2.36 , P= 0.005 ; (4) dog- raising: aOR= 1.76 , P= 0.034 ; (5) the aORs of interval- term exposure to small dosage X- ray was 0.49 , P= 0.015 ,and freque ntly catching cold was 0.67 , P= 0.024 ; (6)the P- value of different occupations was more than 0.05 ;cigarette smoking OR= 1. 01 , P= 0.897 ;giving up smoking OR= 1.17 , P= 0.07 3 ;alcohol-drinking aOR= 1.01 , P= 0.414 ; hair- dyes OR= 1.06 , P= 0.850 ; hair- perms OR= 1.26 , P= 0.438 ;socioeconomic level OR= 1.00 , P= 1.000 and with introversive character OR= 1.26 , P= 0.266 . Conclusions (1)Factors that might increase the risk of su ffering from malignant lymphomas would include direct contact to organic solvent s and some pesticides (organic phosphorus,chrysanthester and organic nitride),in take of aspirin,as well as dog-raising.(2) Regular exposure to small dosage X - ray and frequently catching cold seemed to decrease the risk of suffering fr om ML.(3) Occupation,smoking,giving up smoking,alcohol-drinking,hair-dyes,hair -perms,socioeconomic level and introversive character showed no significant re lations to the risk of suffering from ML in this study.

关 键 词：四川 恶性淋巴瘤 发病因素 环境因素 病例 

分 类 号：R733.1[医药卫生—肿瘤]