赣南稀土矿区白血病病例对照研究  

A case-control study on the risk factors of leukemia in mining areas of rare-e arth in South Jiangxi

作　　者：吴磊[1] 周跃平[1] 钟宏京[1] 

机构地区：[1]江西医学院公共卫生学院流行病学教研室,南昌330006

出　　处：《中华流行病学杂志》2003年第10期879-882,共4页Chinese Journal of Epidemiology

基　　金：国家自然科学基金重点资助项目(3986 90 03)

摘　　要：目的　探索稀土环境污染与白血病的关系。方法　采用 1∶1配对的病例对照研究 ,于2 0 0 1年 11～ 12月在江西赣南稀土矿区选择经骨髓穿刺检查确诊的白血病患者 51例 ,收集相关的资料进行条件logistic回归分析。 结果　多因素分析提示主要的危险因素是 :经常饮用河水 (OR =5.543 )、住家距稀土矿距离及生活年限 (OR =3 .3 0 8)、有机磷农药接触史 (OR =3 .0 14 ) ;而经常饮茶(OR =0 .164)提示为保护因素。结论　稀土环境暴露史、有机磷农药接触史与当地白血病发病有关 ,而饮茶对白血病发生具有保护作用 。Objective In order to explore the correla ti on on radioactive contamination of lanthanon to leukemia,and provide clues for t he causes and prevention of leukemia in mining areas of rare-earth elements. Methods 1∶1 matched case- control study was us ed. A total of 51 clinically confirmed leukemia cases, individually matched with controls from general population, were interviewed in mining areas of rare-ear th in South Jiangxi from November to December, 2001.Data were analyzed, using conditional logistic regression. Results The main risk factors would include frequently dr inking water from river ( OR= 5.543 ), distance from residence to rare -earth mine and years for living in the area( OR= 3.308 ), exposure t o organophosphorus pesticide ( OR= 3.014 ). Tea drinking habit appeare d to be a protective factor. Conclusions Leukemia seemed to be related to environmenta l pollution with rare-earth elements around the residential areas and organopho sphorus pesticide exposure.The protective factor of tea drinking habit seemed to be unique in this study,which called for further studies.

关 键 词：赣南地区 稀土矿区 白血病 病例 环境污染 

分 类 号：R733.7[医药卫生—肿瘤] R730.2[医药卫生—临床医学]