电磁脉冲提高抗肿瘤药物的细胞毒性的研究  

Enhancing the Cytotoxicity of Antitumor Drugs through Electromagnetic Pulses

作　　者：杨果[1] 王保义[1] 张弘[1] 陈海川[1] 王子淑[2] 杨孔[2] 孙敬儒[2] 

机构地区：[1]四川大学无线电系,成都610064 [2]四川大学生命科学院,成都610064

出　　处：《生物医学工程学杂志》2003年第3期497-499,共3页Journal of Biomedical Engineering

基　　金：国家自然科学基金资助项目 (60 0 710 2 4)

摘　　要：以 Hela细胞为实验材料 ,研究在电磁脉冲的作用下细胞发生电穿孔后抗肿瘤药物环磷酰胺所产生的细胞毒性。通过比较电穿孔组和对照组中抗肿瘤药物的细胞毒性的差异 ,发现电穿孔组的细胞毒性有了明显的提高 ,这说明电磁脉冲在一定条件下能够提高抗肿瘤药物的细胞毒性 ,从而为以后肿瘤的临床治疗提供了可靠的依据和可行的途径。We chose Hela cells as research object and studied the cytotoxicity generated by cyclohosphamide, an antitumor drug, after cell electroporation by the use of electromagnetic pulses. Comparison between the electroporation group and the contrast group revealed the greatly enhanced cytotoxicity of the electroporation group,indicating that under some conditions electromagnetic pulses can enhance the cytotoxicity of antitumor drugs. The results of this study provide reliable evidences and a feasible approach for clinical treatment of tumor.

关 键 词：电磁脉冲 抗肿瘤药物 细胞毒性 环磷酰胺 电穿孔 肿瘤治疗 

分 类 号：R73-36[医药卫生—肿瘤]