用近红外光谱对组织氧测量方法的研究  

THE STUDY OF METHODS FOR MEASURING TISSUE OXYGENATION BY USING NIRS

作　　者：黄岚[1] 田丰华[1] 丁海曙[1] 王广志[1] 腾铁超[1] 

机构地区：[1]清华大学生物医学工程系,北京100084

出　　处：《红外与毫米波学报》2003年第5期379-383,共5页Journal of Infrared and Millimeter Waves

基　　金：国家自然科学基金 (批准号 697780 2 4);清华大学基础研究基金(批准号JC2 0 0 10 2 2 )资助项目~~

摘　　要：在多层生物组织模型下 ,提出了一种利用近红外光谱技术定量无损检测组织氧饱和度的方法 .讨论了受试者具有不同的外层组织时 ,如何采用适当的校准方法使半定量测量组织血氧浓度变化值具有可靠性和可比性 ;自行设计的监测系统 ,结构较为简洁 ,其探头包括光源和 2个检测器 ,光源采用双波长LED ,检测器为集成光学器件 ,2个检测器分别放置在与光源不同距离的位置上 ;以 2 4 0mmHg压力进行人体前臂组断 ,氧合血红蛋白HbO2、还原血红蛋白Hb的浓度变化和组织氧饱和度tSO2 的测试结果与时间分辨光谱TRS方法所得结果一致 ;系统基线平稳 。Based on the model of multilayered biological tissue, a method to measure tissue oxygenation saturation by using noninvasive near infrared spectroscopy was present. For the subjects with different constructions and scales of their overlaying tissue, the correction method which make results reliable and comparable in semi-quantitative measuring change in tissue blood oxygenation was proposed. A new compact monitoring instrument which includes a probe with a dual wavelength LED and two integrated optical detectors at different distance from light source was designed and developed. During the ischaemia of forearm induced by 240mmHg pressure with inflating cuff, the result of concentration changes in oxyhemoglobin, deoxyhemoglobin and the value of tSO(2) is consistent with the foreign reports by TRS methods. It shows that the monitoring system is very stable and feasible.

关 键 词：近红外光谱 多层生物组织 氧 无损监测技术 饱和度 Lambert-Beer定律 集成光学器件 人体组织学 

分 类 号：R329.25[医药卫生—人体解剖和组织胚胎学] TN219[医药卫生—基础医学]