乳腺癌基膜LN及Ⅳ型胶原免疫组化研究  

STUDY ON BASEMENT MEMBRANE IN BREAST CARCINOMA

作　　者：张庆慧[1] 刘洪琪[1] 李素英[1] 于佩良[2] 

机构地区：[1]山东医科大学病理解剖学教研室 [2]山东医科大学

出　　处：《山东医科大学学报》1992年第1期42-44,共3页Acta Academiae Medicinae Shandong

摘　　要：应用免疫组化技术对168例乳腺病变的基膜特异性抗原层粘连蛋白和Ⅳ型胶原进行定位检测。结果:乳腺良性病变和导管内癌的基膜为连续细线状;导管癌早期浸润区局部基膜呈碎颗粒状或完全消失;大部分浸润癌的癌巢周边无基膜,少部分有染色较弱的不连续线状或颗粒状基膜物质围绕。统计结果表明,乳腺癌的基膜表达能力与肿瘤的组织学分级有关(P<0.025),与肿瘤的大小、临床分期、腋窝淋巴结转移及预后无关(P皆>0.05)。The immunohistochemical technique was used in the detec-tion of specific components of basement membrane;laminin and type Ⅳ colla-gen,in 168 cases of breast lesion.The results showed that the BM was con- tinuous and linear in benign lesion and intraductal carcinoma.The conti-nuity of BM was broken in case of early invasion.The complete or fragmental BM was seen surrounding nests of infiltrating carcinoma in some ases.Statisti- cally,the formation of BM was correlated with differentiation of the tumor (P<0.025)but not with ize,staging,metastasis and prognosis(P■0.05).Broken of BM as a maker of early invasion was therefore justifiable and presence of BM enclosing infiltrating tumor nest was an indicator of better differentiation of the tumor.

关 键 词：乳腺肿瘤 癌 基膜 病理学 胶原 

分 类 号：R737.902[医药卫生—肿瘤]