Pathomorphological study on location and distribution of Kupffer cells in hepatocellular carcinoma  

作　　者：Kai Liu Xu He Xue-Zhong Lei Lian-San Zhao Hong Tang Li Liu Bing-Jun Lei Division of Molecular Biology of Infectious Disease Key Laboratory of Biotherapy of Human Disease,Ministry of Education,West China Hospital of Sichuan University,Chengdu 610041,Sichuan Province,China 

出　　处：《World Journal of Gastroenterology》2003年第9期1946-1949,共4页世界胃肠病学杂志（英文版）

基　　金：the National Natural Science Foundation of China, No.39670812

摘　　要：AIM: To clarify the location and distribution of Kupffer cells in hepatocellular carcinoma (HCC), and to investigate their role in hepatocarcinogenesis.METHODS: Kupffer cells were immunohistochemically stained by streptavadin-peroxidase conjugated method (S-P). The numbers of Kupffer cells in cancerous, para-cancerous and adjacent normal liver tissues of 48 HCCs were comparatively examined.RESULTS: The mean number of Kupffer cells in cancerous,para-cancerous and adjacent normal liver tissues was 12.7±6.8, 18.1±8.2 and 18.9±7.9 respectively. The number of Kuppfer cells in cancerous tissues was significantly lower than that in para-cancerous tissues (t=2.423, P＜0.05) and adjacent normal liver tissues (t=2.52t, P＜0.05). As tumor size increased, the number of Kupffer cells in cancerous tissues significantly decreased (F=4.61, P＜0.05). Moreover,there was also a significant difference in the number of Kupffer cells among well-differentiated, moderately-differentiated and poorly-differentiated cases(F＝4.49, P＜0.05).CONCLUSION: This study suggests that decrease of Kupffer cells in HCCs may play an important role in the carcinogenesis of HCC, the number of Kupffer cells in HCC is closely related to the size and differentiation grade of the tumor.AIM:To clarify the location and distribution of Kupffer cells in hepatocellular carcinoma(HCC),and to investigate their role in hepatocarcinogenesis. METHODS:Kupffer cells were immunohistochemically stained by streptavadin-peroxidase conjugated method(S-P).The numbers of Kupffer cells in cancerous,para-cancerous and adjacent normal liver tissues of 48 HCCs were comparatively examined. RESULTS:The mean number of Kupffer cells in cancerous, para-cancerous and adjacent normal liver tissues was 12.7±6.8,18.1±8.2 and 18.9±7.9 respectively.The number of Kuppfer cells in cancerous tissues was significantly lower than that in para-cancerous tissues(t=2.423,P<0.05)and adjacent normal liver tissues(t=2.521,P<0.05).As tumor size increased,the number of Kupffer cells in cancerous tissues significantly decreased(F=4.61,P<0.05).Moreover, there was also a significant difference in the number of Kupffer cells among well-differentiated,moderately-differentiated and poorly-differentiated cases(F=4.49,P<0.05). CONCLUSION:This study suggests that decrease of Kupffer cells in HCCs may play an important role in the carcinogenesis of HCC,the number of Kupffer cells in HCC is closely related to the size and differentiation grade of the tumor.

关 键 词：肝细胞癌 枯否细胞 位置分布 发病机制 

分 类 号：R735.7[医药卫生—肿瘤]