西南地区鼻和鼻型NK/T细胞淋巴瘤的临床病理特征及预后分析  

Clinicopathologic features and prognostic factors of nasal and nasal-type NK/T lymphoma in south-west part of China

作　　者：唐琼兰[1] 刘卫平[1] 李甘地[1] 徐缓[1] 杨帆[1] 陈德忠[1] 

机构地区：[1]四川大学华西医院病理科,成都610041

出　　处：《肿瘤》2003年第5期411-413,共3页Tumor

基　　金：国家自然科学基金资助项目 (编号 :3 910 0 0 47)

摘　　要：目的　分析西南地区鼻和鼻型NK/T细胞淋巴瘤的临床病理特征及影响预后的因素。方法　分析 12 0例鼻和鼻型NK/T细胞淋巴瘤的病理形态及免疫表型、临床特点、治疗和生存情况。结果　 12 0例患者总的 5年生存率为 5 4 .1%。大型瘤细胞生存率较中小型瘤细胞低 (P <0 .0 1) ,病变中有坏死及血管浸润者生存率明显低于对照组 (P <0 .0 5 ) ,而瘤细胞分布及患病年龄与预后关系不大 ,临床Ⅰ～Ⅱ期与Ⅲ～Ⅳ期两组病例生存率差异有显著性 (P <0 .0 1) ,累及多个部位、伴有穿孔及全身症状者生存率低于对照组 (P <0 .0 5 )。综合治疗疗效优于单一治疗及未治疗组 (P <0 .0 1) ,单一治疗近期疗效好 ,而远期疗效与未治疗组差异无显著性 (P >0 .0 5 )。CoxRegression分析结果亦表明瘤细胞大小、分期及治疗方法与预后密切相关。 结论　瘤细胞大小、坏死、血管浸润、穿孔、B症状、分期、病变范围和治疗方法与鼻和鼻型NK/T细胞淋巴瘤的预后相关 ,其中瘤细胞大小、分期和治疗方法是其主要的预后因素。Objective To investigate the clinicopathologic features, prognostic factors and the prognosis of nasal and nasal-type NK/T-cell lymphoma in south-west of China. Methods The clinicopathologic features, immunophenotypes and treatment of 120 patients with nasal and nasal-type NK/T-cell lymphoma were analyzed. Results The overall 5-year survival rate for all cases was 54.1%, and correlated well with the size of tumor cells, necrosis, angiocentricity, the stage, sites of involvement, and perforation(P<0.05); but not with the distribution of tumor cells and the age of patients at the presentation (P>0.05). The overall survival rate of patients with combined therapy was higher than that of patients with radiotherapy or chemotherapy alone or untreated ones (P<0.01). Even though the patients with radiotherapy or chemotherapy alone had a relatively favorable short-term results, the long-term curative effect for those patients was not better than that of untreated patients (P>0.05). Furthermore, the size of tumor cells, stage, and treatment were well correlated with the prognosis of these patients by Cox Regression. Conclusion The prognosis of nasal and nasal-type NK/T-cell lymphoma was significantly correlated with the size of tumor cells, necrosis, angiocentricity, stage, sites of involvement, perforation and treatment, especially with the size of tumor cells, stage, and treatment.

关 键 词：西南地区 鼻肿瘤 鼻型NK/T细胞淋巴瘤 病理特征 预后 

分 类 号：R739.62[医药卫生—肿瘤] R733.4[医药卫生—临床医学]