身体质量指数和上海市男性肺癌关系的前瞻性队列研究  

Association of body mass index with risk of lung cancer: evidence from a middle-age men cohort in Shanghai

作　　者：刘恩菊[1] 王学励[1] 袁剑敏[2] 高玉堂[1] 

机构地区：[1]上海交通大学肿瘤研究所 [2]美国南加州大学,ca900899175

出　　处：《肿瘤》2003年第5期360-363,共4页Tumor

基　　金：美国南加州大学和上海市肿瘤研究所合作项目

摘　　要：目的　研究身体质量指数 (BMI)和男性肺癌之间的关系。方法　采用前瞻性队列研究方法 ,1986～ 1989年在上海市区建立了 1个包括 180 0 0人的男性队列 ,以后每年随访 1次 ,至 2 0 0 0年 7月共收集到肺癌新发病例 374人。结果　身体质量指数越高 ,患肺癌的危险性越低。以身体质量指数五分位的最低组作参比 ,调整了年龄、文化程度和吸烟情况等混杂因素后 ,其它 4组的相对危险度依次为 0 .8、0 .8、0 .6和 0 .7,趋势检验P值 =0 .0 0 2。按吸烟状况进行分层分析后发现在当前吸烟者中 ,身体质量指数和患肺癌危险性的负相关关系依然存在 ,但是在从不吸烟组中 ,由于肺癌发病例数太少 ,目前还无法得出结论。按肺癌的不同组织学类型进行分析 ,发现身体质量指数和肺腺癌的关系较明显。结论　身体质量指数可能与上海男性肺癌危险性之间存在负相关关系。Objective To investigate the relationship between body mass index (BMI) and lung cancer risk among men in urban Shanghai, China. Methods Between January 1,1986 and September 30,1989, a total of 18,244 male residents of urban Shanghai were recruited in the prospective cohort study. The eligible study subjects were ages 45 to 64 years of age and without history of cancer. Through July 2000 (14 years follow-up), 374 new cases of lung cancer were identified in the cohort. Cox regression model was used to estimate the adjusted relative risks (RRs) and 95% confidence intervals(CIs). Results The risk of lung cancer decreased with increase of BMI. After adjustment for some potential confounding factors, a relative risk of 0.7 (highest versus lowest quintile of BMI) was observed (P-trend=0.002). Stratified by smoking status, an adverse association of body mass index with lung cancer risk still exists among current smokers. There were too few cases of lung cancer to draw a valid result among never smokers. The result also showed that the association of BMI with risk of lung adenocarcinoma is more apparent than other histologic subtypes. Conclusion An adverse association of BMI with lung cancer risk may exist among men in Shanghai.

关 键 词：身体质量指数 上海市 男性 肺癌 前瞻性队列研究 

分 类 号：R734.2[医药卫生—肿瘤]