α-连接素表达与胃癌生物学行为的关系  

Relationship between abnormal expression of α-catenin and biological behaviors of gastric carcinoma

作　　者：徐采朴[1] 周永宁[1] 陈渝[2] 

机构地区：[1]中国人民解放军第三军医大学西南医院全军消化专科中心,重庆市400038 [2]中国人民解放军第三军医大学西南医院烧伤研究所,重庆市400038

出　　处：《世界华人消化杂志》2003年第9期1275-1278,共4页World Chinese Journal of Digestology

摘　　要：目的:检测α-连接素在胃癌及癌前组织的表达,并分析其与临床病理学及患者生存的关系。方法:采用免疫组织化学方法检测163例胃癌、44例异型增生、25例肠化生、28例萎缩性胃炎石蜡标本的α-连接素表达水平。结果:肠化生以及对照组胃黏膜均保留正常的细胞膜染色;萎缩性胃炎组仅有1例异常染色。α-连接素在胃癌异常表达率为76％;异型增生为43％。BorrmannⅢ型和BorrmannⅣ型α-连接素异常表达率显著高于 Borrmann Ⅰ型和Borrmann Ⅱ型(P<0.01)。α-连接素在管状腺癌、黏液腺癌及印戒细胞癌的异常表达率分别为78％、79％和91％,显著高于乳头状腺癌(47％)(P<0.01)。α-连接素在肠型胃癌和弥漫型胃癌的异常表达率分别为68％(73/108)和95％(38/40),二者之间具有显著性差异(P<0.01),α-连接素表达与胃癌浸润深度、淋巴结转移和远处转移无关(分别P>0.05),α-连接素正常表达患者并未显示生存优势。结论:胃癌组织广泛存在α-连接素表达异常,且异常表达与分化程度差密切相关,α-连接素表达异常可能是胃癌发生、发展过程中的早期事件。AIM: To assess the expression of α-catenin in gastric car- cinoma and to determine its relation with tumor clinico- pathological features and patient survival. METHODS: Immunohistochemical staining of α-catenin was performed for 163 cases of gastric carcinomas,44 cases of gastric dysplasia and 25 cases of intestinal metaplasia, and 28 cases of atrophic gastritis. RESULTS: Normal membranous staining was observed in intestinal metaplasia and control biopsy specimens for α- catenin. 76 % of tumors and 43 % of gastric dysplasia were stained abnormally for α-catenin. Only one of atrophic gastritis showed abnormal staining. Abnormal α-catenin expression occurred more significantly in Borrmann Ⅲ/ Ⅳ type than in Borrmann Ⅰ/Ⅱ type (P<0.01) A signifi- cantly higher proportion of signet-ring (91 %), mucinous (79 %) and tubular adenocarcinomas (78 %) showed ab- normal α-catenin expression compared with papillary adenocarcinomas (47 %) (P<0.01) Morever, abnormal α-catenin staining occurred more frequently in diffuse type (95%, 38/40) than in intestinal type tumors (68 %, 73/108) P<0.01). No association was found between abnormal α-catenin and tumour invasive depth, lymph node metastasis and distance metastasis (P>0.05, respectively). A survival advantage was not noted in the tumors retaining normal staining of α-catenin. CONCLUSION: Abnormal expression of α-catenin occurs frequently in gastric carcinoma, and is closely related to its poor differentiation. Abnormal expression of α-catenin in gastric dysplasia may be an early event in tumorigenesis.

关 键 词：Α-连接素 胃癌 生物学行为 免疫组织化学 临床病理学 细胞黏附功能 

分 类 号：R735.2[医药卫生—肿瘤]