亚慢性苯暴露对大鼠组织中内皮素和一氧化氮浓度的影响  

An effects of subchronic benzolism on the concentrations of endothelin and nitric oxide in organizations in rats

作　　者：张强[1] 林立[1] 王彦英[2] 徐雷 

机构地区：[1]济宁医学院职业卫生与环境医学研究所,山东济宁272013 [2]济宁医学院附属医院 [3]山东省梁山县妇幼保健院检验科

出　　处：《中国行为医学科学》2003年第4期367-368,共2页Chinese Journal of Behavioral Medical Science

基　　金：山东省教育厅基金课题 (项目号 :J97K60 )

摘　　要：探讨亚慢性苯暴露对组织中血管内皮活性物质的影响及意义。方法　对不同染毒剂量、不同染毒时间家兔大脑、肝、肾组织中的内皮素 (ET)、一氧化氮 (NO)进行了测定。结果　与染毒前和对照组比较 ,染毒后家兔组织中ET有明显增高趋势、NO有明显下降趋势 (P <0 .0 5 ,P <0 .0 1) ,随染毒时间延长变化更明显。结论　亚慢性苯暴露所致的血管内皮活性物质的紊乱 ,可造成组织缺血缺氧 ,并可能是苯所致造血功能抑制以外的毒性表现。Objective To study effects of subchronic benzolism on the vascular endothelial active substance and their meaning.Methods The concentrations of endothelin(ET) and nitric oxide(NO) in brain, liver and kidney were measured in different exposure dose and different period in rats. Result Compared with control group, the concentrations of ET of the organizations had an increasing tendency (P<0.05,P<0.01), and the concentrations of NO of the organizations had a decreasing tendency (P<0.05,P<0.01) in the groups exposed bezene. Conclusion The disorders of vascular endothelial active substance in organizations induced by subchronic benzolism can result in ischaemia and hypoxia in organizations,which maybe another toxicity of bezene.

关 键 词：亚慢性 苯暴露 内皮素 一氧化氮 组织 

分 类 号：R363[医药卫生—病理学]