糖尿病视网膜病变时TXB_2及6-Keto-PGF_(1α)的动态变化及临床意义  

Clinical significance of TXB_2 and 6-keto-PGF_(1α) levels dynimie changes in patients with diabetic Retinopathy

作　　者：郭秀瑾[1] 李永军[2] 王长龄[1] 张玉华[3] 

机构地区：[1]河北医科大学第二医院眼科,河北石家庄050000 [2]河北医科大学第二医院检验科,河北石家庄050000 [3]河北医科大学第二医院核医学科,河北石家庄050000

出　　处：《中国实验诊断学》2003年第5期423-424,共2页Chinese Journal of Laboratory Diagnosis

摘　　要：目的　探讨TXA2 及PGI2 在糖尿病视网膜病变时的变化规律及临床意义。方法　运用放射免疫方法对 35例糖尿病视网膜病变临床前期患者、36例糖尿病视网膜病变背景期患者、32例糖尿病视网膜病变增殖期患者以及 35例健康人进行TXB2 及 6 Keto PGF1α的定量检测。结果　各期糖尿病视网膜病变患者的TXB2 及 6 Keto PGF1α检测值与对照组均有显著性差异 ,糖尿病视网膜病变临床前期、背景期及增殖期之间的TXB2 及 6 Keto PGF1α水平亦显著不同。结论　检测糖尿病患者的TXB2 及 6 Keto PGF1α水平对糖尿病视网膜病变的早期诊断和预防以及临床治疗具有重要意义。Objective To investigate changes of TXB 2 and 6-keto-PGF 1α levels in patients with diabetic retinopathy.Methods TXB 2 and 6-keto-PGF 1α levels of 35 cases with subclinical diabetic retinopathy (NDR);36 cases with background diabetic retinopathy (BDR);32 cases with proliferative diabetic retinopathy(PDR) and 35 cases of normal control were detected by Radioimmunoassay (RIA).Results There were significantly differences in TXB 2 and 6-keto-PGF 1α levels between those of the normal control and retinopathy groups.Levels of TXB 2 and 6-keto-PGF 1α were significantly different among groups of NDR,BDR and PDR.Conclusion Detecting TXB 2 and 6-keto-PGF 1α is valuable for patients with diabetic in early clinical diagnosis and treatment.

关 键 词：糖尿病 视网膜病变 TXB2 6-Keto-PGFlα 血栓素B2 6-酮-前列腺素Flα 

分 类 号：R774.1[医药卫生—眼科]