前伸青春期大鼠下颌后翼外肌细胞膜乙酰胆碱受体特性变化的研究  

Characteristic Changes of Acetylcholine Receptor in Rat Lateral Pterygoid Muscles after Functional Mandibule Advancement

作　　者：陈开云[1] 罗颂椒[2] 

机构地区：[1]广东省口腔医院正畸科,510280 [2]四川大学华西口腔医院正畸科

出　　处：《华西口腔医学杂志》2003年第5期400-402,共3页West China Journal of Stomatology

基　　金：国家自然科学基金资助项目 (编号 30 1 71 0 2 4 )

摘　　要：目的　研究功能矫形前伸青春期大鼠下颌后 ,翼外肌细胞膜乙酰胆碱受体最大结合容量和亲和性的变化 ,探讨功能矫形的神经肌肉调控机理。方法　选用 4 0只 5周龄SD雄性大鼠 ,随机分为实验组和对照组各 2 0只。实验组大鼠戴自制上颌功能矫治器 ,引导下颌前伸 ,对照组不做任何处理 ,分别在实验第 1、3、7、14天处死大鼠 ,采用放射受体分析法测定 2组大鼠翼外肌肌细胞膜上乙酰胆碱受体的最大结合容量和亲和常数。结果　实验组大鼠翼外肌细胞膜上乙酰胆碱受体最大结合容量明显大于对照组 ,具有高度亲和力。Objective\ The purpose of this study was to evaluate the maximum binding(Bmax) and affinity(Kd value)changes of acetylcholine receptor (n_AchR) in rat lateral pterygoid muscles after functional mandibule advancement.Methods\ 40 five_weeks_old male Sprague_Dawley rats were equally divided into experimental and control group. The mimic functional appliances were used in experiment group and the rats were killed after 1, 3, 7, 14 days. Radio_ligand binding assay (RBA) was applied to determine the maximum binding(Bmax) and Kd value of n_AchR of lateral pterygoid muscle.Results\ The Bmax of n_AchR in experimental group was higher than that in control group and the Kd value always kept in high level.Conclusion\ The functional orthopedics can increase the Bmax of n_AchR in rapid growing rat lateral pterygoid muscles.

关 键 词：青春期 大鼠 翼外肌细胞膜 乙酰胆碱受体 口腔正畸学 

分 类 号：R783.5[医药卫生—口腔医学]