复方丹参注射液防治放疗后颌间挛缩初探  

Dan Shen compound injection prevent radiation-induced intermaxillary contracture

作　　者：刘伟东[1] 王一龙[1] 胡向荣[1] 江银华[1] 

机构地区：[1]丽水市人民医院,浙江丽水323000

出　　处：《临床口腔医学杂志》2003年第10期613-614,共2页Journal of Clinical Stomatology

摘　　要：目的 :研究复方丹参注射液对放疗后颌间挛缩的防治作用。方法 :选择 36例双耳前野常规分割放疗病例 ,受照剂量为 48-80Gy ,治疗时间在 35～ 5 4d之间。 36例随机分为 2组。实验组在放疗期间和放疗后应用复方丹参注射液 ,对照组则不应用。放疗结束后 2年测量张口度。结果 :实验组张口度 <3cm的发生率为 33.3%(5 / 15 ) ;<1cm的为 6 .7%(1/ 15 ) ;对照组张口度 <3cm的发生率为 5 7.1%(12 / 2 1) ;<1cm的为 9.5 %(2 / 2 1)。两组间秩和检验 ,差异有显著性 (P <0 .0 5 )。结论 :复方丹参注射液是一种安全、有效的防治放疗后颌间挛缩的药物 ,有进一步研究、应用价值。Objective:This study was designed to investgate the outcome of Dan Shen compound preventing radiation-induced intermaxillary contrature.Method:The 36 patiants received radical conventional radiotherapy both front ear field were eligible for this study. The total dose were 48-80 gray and the overall treatment time were 35-54 days. They were randomly divided into two groups. The test group (n=15)were injected Dan Shen compound during and after irradition .There were no Dan shen compound for the control group. The endpoint was the distance between two dens incisivus medialis (DDIM).Eveyone was measured after two years.Result:The patient of DDIM<3 cm in test group was 33.3%(5/15) ; the DDIM<1 cm in test group was 6.7%(1/15);the DDIM<3 cm in control group was 57.1%(12/21) ; the DDIM<1 cm in control group was 9.5%(2/21) . There were singnificant difference between two groups(P< 0.05) .Conclusion:The data show that Dan shen compound injection is a safe-effective prophyactic for radiation-induced intermaxillary contrature.

关 键 词：颌间挛缩 复方丹参注射液 放射疗法 放射损伤 

分 类 号：R730.55[医药卫生—肿瘤]