利用毛细管电泳测定肝癌患者血清中维生素K的含量  

Quantitative analysis of vitamin K in serum of liver can cer using capillary electrophoresis

作　　者：梁红艳[1] 李正军[1] 姜晓峰[1] 

机构地区：[1]哈尔滨医科大学第二临床医学院实验诊断学教研室,黑龙江哈尔滨150086

出　　处：《哈尔滨医科大学学报》2003年第5期422-425,共4页Journal of Harbin Medical University

摘　　要：目的　初步建立维生素K的毛细管电泳检测方法 ,并对肝癌患者血清中维生素K含量的变化进行观察研究。方法　利用毛细管电泳对正常人、肝硬化后肝癌及其它型肝癌患者血清中维生素K1 及K2 含量进行比较。结果　正常人血清中维生素K1 和维生素K2 水平明显高于肝癌患者 ;肝硬化后肝癌患者与其他肝癌患者的维生素K1 水平有显著差异 ,而维生素K2 在所有肝癌患者中差异不大。结论　维生素K的缺乏与肝癌的发生有一定关系 ,维生素K可能成为治疗肝癌药物之一。Objective To set up an effect method in order to quantitatively a nalyze vitamin K in serum, and to observe the changes of vitamin K in serum of liver cancer. Methods The levels of vitamin K in serum of normal human and patien t with liver cancer after cirrosis or other liver cancer were determined by capi llary electrophoresis. Results The levels of vitamin K 1 and K 2 in normal human serum w ere higher than that in the liver cancer;the levels of vitamin K 1 were signifi c antly different between liver cancer after cirrosis and other liver cancer, but the levels of vitamin K 2 were not. Conclusion The deficiency of vitamin K is related to liver cancer, vitamin K will become one of the effective drugs to treat liver cancer.

关 键 词：毛细管电泳 含量测定 肝癌 血清 维生素K 

分 类 号：R735.7[医药卫生—肿瘤]