nm23/NDPK在前列腺癌中的表达及意义  

The Study of nm23/NDPK Expression in Human Prostate Cancer

作　　者：臧晋[1] 严春寅[1] 张炜[1] 

机构地区：[1]苏州大学附属第一医院泌尿外科,苏州215006

出　　处：《苏州大学学报（医学版）》2003年第5期548-550,共3页Suzhou University Journal of Medical Science

摘　　要：目的　研究nm2 3/NDPK在前列腺癌中表达的意义。方法　用免疫组织化学方法检测 4 0例前列腺癌标本中nm2 3/NDPK的表达情况。结果　在 4 0例前列腺癌标本中nm2 3/NDPK的阳性表达为 5 7.5 0 % (2 3/ 4 0 ) ,nm2 3/NDPK的表达随病理分化程度降低而下调 ;转移组 (36 .84 % )明显低于非转移组 (76 .19% ) ,P <0 .0 5。随前列腺癌Whitmore分期的增高 ,nm2 3/NDPK表达明显下调。结论　nm2 3基因在前列腺癌侵袭转移过程中发挥重要作用 ,检测nm2Objective To study the role of nm23/NDPK in carcinogenesis and metastasis of human prostate cancer. Methods The expression of nm23/NDPK was analyzed by means of immunohistochemistry in 40 patients with prostate cancer. Results Among 40 case 23(57.5%) had strongly positive expression of nm23/NDPK in the cytoplasm. The strongly positive expression of nm23/NDPK showed down-regulation following pathological stage progress and differentiation. Compared with the group of non-metastasis(76.19%), the positive expression of nm23/NDPK in the group of metastasis(36.84%) decreased significantly. Conclusion Measuring the expression of nm23 may be a great aid in evaluating the biological behavior of human prostate cancer and predicting tumor recurrence and progression.

关 键 词：前列腺癌 NM23/NDPK 免疫组织化学 

分 类 号：R737.25[医药卫生—肿瘤]