保护赖氨酸的制备工艺  

Synthesis procedure for protected lysine

作　　者：魏浩[1] 王玲[1] 韦萍[1] 朱颐申[1] 

机构地区：[1]南京工业大学制药与生命科学学院,江苏南京210009

出　　处：《南京工业大学学报（自然科学版）》2003年第4期45-48,共4页Journal of Nanjing Tech University(Natural Science Edition)

摘　　要：保护L-赖氨酸是固相多肽合成的重要原料,其商品价格居高不下。采用Fmoc和Boc保护策略,对L-Lys的α-氨基和ε-氨基保护进行了制备工艺研究,优化选择了其制备条件,将Fomc-L-Lys(Boc)的产品产率由76％提高到88％,产品纯度达到99.6％。The protected L-Lysine is an important material of solid phase peptide synthesis, which price is always high. This paper used Fmoc and Boc protection strategy, studied the synthesis procedure of protection for α-NH2 and ε-NH2 of L-Lysine, chose the optimium synthesis condictions. The yield of Fmoc-L-Lys(Boc) was improved from 76% to 88% . The purity of product was 99.6% .

关 键 词：赖氨酸 Α-氨基 ε-氨基 FMOC BOC 固相多肽 氨基保护 

分 类 号：TQ936.16[化学工程] TQ464.7