丙烯酰胺对小鼠骨髓染色体畸变和微核率的影响  

THE EFFECTS OF ACRYLAMIDE ON FREQUENCY OF CHROMOSOMAL ABERRATIONS AND MICRONUCLEUS IN THE BONE MORROW OF MICE

作　　者：李秀云[1] 刘旭红[1] 赵五红[1] 

机构地区：[1]山西医学院环境卫生学教研室

出　　处：《山西医学院学报》1992年第2期117-118,127,共3页

摘　　要：本文报道丙烯酰胺对小鼠骨髓染色体畸变和微核率的影响。试验剂量分别为25、50、100mg/kg。结果表明,50mg/kg开始使小鼠骨髓细胞染色体畸变及微核率增高,与阴性对照比较有显著差异,有剂量—反应关系。表明丙烯酰胺对小鼠骨髓细胞染色体有损伤作用。In this paper, the effects of acrylamide(AA)monomer on, frequency of chromosomal aberration and micronucleus in the bone marrow of mice was reported. AA was given to the mice in dosage of 25, 50, 100mg/kg. The results showed that AA elevated frequency of chromosomal aberration and micronucleus in middle and high dosage. There was a relationshep between dosage and response. Besides, it indicated that AA induced an injury of the chromosome in the bone marrow of the mice.

关 键 词：染色体畸变 微核试验 丙烯酰胺 

分 类 号：R598.102[医药卫生—内科学]