卡托普利对肾性高血压大鼠主动脉磷脂酶C活性的影响  

Effects of captopril on activity of phospholipase C in aorta in renal hypertensive rat

作　　者：孙银平[1] 王省[2] 白桦[3] 邢东琦[3] 吴立玲[3] 

机构地区：[1]新乡医学院病理生理教研室,河南新乡453003 [2]新乡医学院解剖教研室,河南新乡453003 [3]北京大学医学部病理生理教研室,北京100083

出　　处：《新乡医学院学报》2003年第6期401-402,406,共3页Journal of Xinxiang Medical University

摘　　要：目的　观察肾性高血压主动脉磷脂酶 C(PL C)活性变化及卡托普利对其的影响。方法　制备二肾一夹高血压动物模型作为实验组 ,术后 4周开始给予卡托普利者作为治疗组 ,以未进行二肾一夹者为对照组。术后 4周测定动脉血压 ,8周时测定动脉血压与主动脉组织 PL C活性。结果　与对照组相比 ,实验组 8周大鼠动脉血压显著升高 (P<0 .0 1) ,主动脉组织 PL C活性明显增强 (P<0 .0 5) ;卡托普利显著降低动脉血压与主动脉 PL C的活性 (P<0 .0 5)。结论　肾性高血压主动脉 PL C活性升高 ,Ang 可能通过活化的 PLObjectiveTo observe the effects of captopril o n activity of phospholipase C in aorta in renal hypertensive rats.Meth odsThe animal model of renal hypertension was made with two-kidneys and one-clip as study group;the animals with captopril treatment at 4-8 week s as the treatment group;the animals receiving non-operation as the control gro u p.The blood pressure and the activity of phospholipase C in aorta were measured at 4 week and 8 week.ResultsCompared with control group,the b lood pressure,the activity of phospholipase C significantly increased after op eration at 4th week and 8th week respectively(P<0.01,).The blood pressure ,the activity of phospholipase C significantly decreased in captopril-treate d groups.ConclusionThe activity of phospholipase C in aorta i nduced by AngII may play an important role in renal hypertension.

关 键 词：卡托普利 磷脂酶C 肾性高血压 主动脉 

分 类 号：R363.21[医药卫生—病理学] R544.14[医药卫生—基础医学]