原发性小肝癌三维适形放射治疗疗效及其预后多因素分析  

Therapeutic effects of3-dimensional conformal radiotherapy for small hepatocellular cancers and multi-factor analysis of the prognosis

作　　者：吴德华[1] 陈龙华[1] 

机构地区：[1]第一军医大学南方医院放疗科,广东广州510515

出　　处：《第一军医大学学报》2003年第10期1056-1058,共3页Journal of First Military Medical University

基　　金：广东省自然科学基金重点项目(013056)~~

摘　　要：目的评价三维适形放射治疗(3-DCRT)治疗原发性小肝癌(HCCs)的疗效。方法对42例HCCs患者行3-DCRT治疗,观察疗效并进行预后多因素分析。结果肿瘤局部缓解率为83.3%,1、2、3年累积生存率分别为100%、90.48%、78.57%,平均生存时间48.7个月。多因素分析结果显示性别、肿瘤数目、肿瘤直径对患者生存率的影响具有统计意义(P<0.05)。结论3-DCRT对不能手术治疗的HCCs有较好的疗效,性别、肿瘤数目、肿瘤直径是影响生存率的主要因素。Objective To evaluate the therapeutic effects of 3-dimensional conformal radiation therapy (3-DCRT) for small hepatocellular carcinoma (HCCs) and to analyze the prognostic factors. Methods Forty-two HCCs patients were treated with 3-DCRT and acute effects and survival rates were observed. Kaplan-Meier method was used for survival analysis, and Cox proportional hazard model adopted in multi-factor analysis. Results No evidence of local failure was found in 83.3% of the patients at 3 months after the radiotherapy. The overall 1-, 2-, and 3-year survival rates were 100.00%, 90.48%, 78.57% respectively. Multivariate analysis revealed that the gender, number of tumors, and tumor size were the independent and statistically significant factors affecting the patients' survival (P<0.05). Conclusions3-DCRT is effective and feasible for treating non-operable HCCs, and the gender, number of tumors, and tumor size are the major factors affecting the survival of HCCs patients.

关 键 词：原发性小肝癌 三维适形放射治疗 疗效 预后 影响因素 

分 类 号：R735.7[医药卫生—肿瘤] R730.55[医药卫生—临床医学]