急性脑梗死患者颈动脉斑块与血清C反应蛋白及白细胞计数的关系  

Relationship between the carotid plaque and serum C-reactive protein,leucocytes count in patients with acute cerebral infarction

作　　者：郭毅[1] 周志斌[1] 姜昕[2] 赵宏文[1] 陈实[3] 古坤毅[1] 马可夫[1] 

机构地区：[1]暨南大学医学院第二附属医院神经内科,深圳市518020 [2]暨南大学医学院第二附属医院心内科,深圳市518020 [3]暨南大学医学院第二附属医院老年病科,深圳市518020

出　　处：《临床神经病学杂志》2003年第5期266-268,共3页Journal of Clinical Neurology

摘　　要：目的　研究急性脑梗死患者颈动脉斑块与血清C反应蛋白 (CRP)、白细胞计数的关系。方法　应用颈动脉彩色超声多普勒 (HDI 5 0 0 0型 )检查 12 1例急性脑梗死患者颈动脉内膜 中层厚度 (IMT) ,用散射浊度计法检测血清CRP。根据颈动脉超声检查结果分为斑块组 (IMT≥ 1 2mm)与非斑块组 (IMT <1 2mm)。结果　颈动脉斑块组患者的年龄明显高于正常组 (P =0 0 0 1) ,伴有高血压及糖尿病的例数也明显高于非斑块组 (P <0 0 1,P <0 0 5 )。两组血白细胞计数比较无明显差异 (P >0 0 5 )。颈动脉斑块组患者血CRP水平增高例数多于非斑块组 (P <0 0 5 )。结论　血CRP水平增高对反映急性脑梗死患者颈动脉粥样硬化病变有显著临床意义。Objective To investigate the relationship between carotid plaque and serum C reactive protein(CRP) levels, leukocyte count in patients with acute cerebral infarction(ACI) Methods Carotid duplex examination was performed in 121 patients with ACI by an Advanced Technology Laboratories HDI (high definition imaging) 5000 triplex system Serum CRP was measured by nephelometry Results of carotid ultrasonography were divided into two groups: M1: normal (IMT<1 2 mm) and M2: abnormal (IMT≥1 2 mm) Results The mean age of M2 group was significantly older than that of M1 group( P =0 001) The patients with hypertension and diabetes mellitus in M2 group were significant more than that in M1 group( P < 0 01, P < 0 05) There were no significant difference between the serum leukocyte count of M2 and M1 group( P > 0 05) The number of patient with elevated CRP levels was increased in the M2 group( P < 0 05) Conclusion Elevated CRP levels have a significant clinical index for carotid plaque in patients with ACI

关 键 词：急性脑梗死 颈动脉斑块 血清学检查 C反应蛋白 白细胞计数 彩色超声多普勒 

分 类 号：R743.33[医药卫生—神经病学与精神病学]