VEGF-C在食管鳞癌和神经胶质瘤中的表达及其意义  

Significance and Expression of Vascular Endothelial Growth Factor-C (VEGF-C) in Esophageal Squamous Carcinoma and Glioma

作　　者：逄小红[1] 田铧[1] 刘执玉[1] 李盛梅[1] 刘书涛[1] 田广平[1] 

机构地区：[1]山东大学医学院解剖学教研室,山东济南250012

出　　处：《癌症》2003年第11期1166-1169,共4页Chinese Journal of Cancer

基　　金：山东省自然科学基金(No.Y2000C12)

摘　　要：背景和目的;近几年研究发现,某些恶性肿瘤能表达血管内皮生长因子C(vascular endothelial growth factor-C,VEGF-C),VEGF-C是迄今发现的惟一特异性促淋巴管生长因子。目前恶性肿瘤组织中VEGF-C的表达与肿瘤淋巴转移的关系方面的研究资料尚少。本研究拟通过检测、比较VEGF-C在两种不同转移特性的恶性肿瘤即人食管鳞癌和神经胶质瘤组织中的表达,分析恶性肿瘤组织中VEGF-C的表达与肿瘤淋巴转移的关系。方法:采用免疫组化法检测VEGF-C在72例食管鳞癌(其中淋巴结转移29例;无淋巴结转移43例)和23例神经胶质瘤组织(病理学诊断为星形细胞瘤,Ⅰ～Ⅳ级)中的表达,并对VEGF-C的表达与临床病理因素之间的关系作进一步的分析研究。结果:神经胶质瘤组织中未见VEGF-C抗原表达;食管鳞癌组织VEGF-C阳性表达率为38.88％(28/72),其中VEGF-C阳性表达率在有淋巴结转移组为62.07％(18/29),在无淋巴结转移组为23.26％(10/43),在浸润深度T_2、T_3期为58.82％(20/34),在T_1期为21.05％(8/38),结论:VEGF-C阳性表达与食管 鳞癌的淋巴结转移、浸润深度有关。VEGF-C是促进食管鳞癌经淋巴转移的重要因素。BACKGROUND & OBJECTIVE: The research in recent years has demonstrated that vascular endothelial growth factor-C (VEGF-C) is expressed in certain malignant tumor cells, and up to now VEGF-C is the only growth factor specific for lymphangiogenesis. The relationship between the VEGF-C expression in malignant tumor tissues and lymphatic metastasis is still scarcely reported. This study was designed to compare the VEGF-C expression in human esophageal squamous carcinoma and glioma, and then to analyze the relationship between the VEGF-C expression and tumor lymphatic metastasis. METHODS: The expression of VEGF-C antigen was detected with immunohistochemical method in 72 human esophageal squamous carcinomas (29 cases with lymph node metastasis,43 cases without lymph node metastasis) and 23 human gliomas (diagnosed pathologically as astrocytoma in grades I to IV ), followed by the further analysis on the relationship between VEGF-C expression and clinicopathological parameters. RESULTS: The expression of VEGF-C antigen was not found in any gliomas, while the positive VEGF-C expression rate achieved 38. 88% (28/72) in the human squamous carcinoma, with 62. 07% (18/29) in the cases with lymph node metastasis, 23. 26% (107 43) in the cases without lymph node metastasis, 58. 82% (20/34) in the T2 and T3 of invasion depth cases, and 21.05% (8/38) in the T1 of invasion depth cases. CONCLUSION: The expression of VEGF-C antigen was significantly associated with lymph node metastasis and invasion depth in esophageal squamous carcinoma. VEGF-C may act as a key factor in the facilitation of lymphatic metastasis in esophageal squamous carcinoma.

关 键 词：VEGF-C 食管鳞癌 神经胶质瘤 血管内皮生长因子C 肿瘤淋巴转移 

分 类 号：R735.1[医药卫生—肿瘤] R739.4[医药卫生—临床医学]