尿细胞角蛋白检测在诊断尿路移行细胞癌中的价值  

Value of urinary cytokeratin 8 and 18 as a diagnostic marker for transitional cell carcinoma

作　　者：李涛[1] 陈梓甫[1] 林成栋[2] 高祥勋[1] 詹汉雄[1] 陈文榜[1] 何延瑜[1] 詹天棋[1] 张延榕[1] 

机构地区：[1]福建省立医院泌尿外科,福州350001 [2]福建省立医院检验科,福州350001

出　　处：《中华泌尿外科杂志》2003年第11期774-776,共3页Chinese Journal of Urology

摘　　要：目的　评价尿细胞角蛋白检测在诊断尿路移行细胞癌 (TCC)中的价值。　方法　采用ELISA法检测 5 2例尿路TCC及 86例泌尿系非TCC患者尿液中细胞角蛋白 8和 18的含量 (UBC值 )。　结果　TCC患者尿UBC均值为 34.8μg/L ,与泌尿系非TCC患者 9.4 μg/L比较 ,差异有非常显著性意义 (P <0 .0 1)。以 8.4 μg/L为最适临界值 ,尿细胞角蛋白诊断TCC的敏感性为 73.1% ,特异性为 73.3% ,阳性预测值为 6 2 .3% ,对复发性膀胱TCC的敏感性达 10 0 %。　结论　尿细胞角蛋白检测是诊断尿路TCC的一种较为敏感、特异且无创的方法 ,适用于膀胱癌患者的术后随访。Objective To determine the clinical efficacy of cytokeratin 8 and 18 as a novel urine marker for transitional cell carcinoma (TCC) of urinary tract. Methods Urinary concentrations of cytokeratin 8 and 18 were determined by an enzyme-linked immunosorbent assay (ELISA) in 52 cases of TCC and 86 cases of other urological conditions. Results The urinary values of cytokeratin 8 and 18 in the TCC patients (mean 34.8 μg/l) were significantly higher than those in the patients without TCC (mean 9.4 μg/l)(P<0.01).At an optimal threshold value of 8.4μg/l,the sensitivity of urinary cytokeratin 8 and 18 for detection of TCC was 73.1%,the specificity was 73.3%,the positive predictive value was 62.3%,and the sensitivity for detection of recurrent TCC of the bladder was 100%. Conclusions Urinary cytokeratin 8 and 18 is a sensitive,specific and noninvasive diagnostic marker for detection of TCC,and may be more suitable to the postoperative follow-up of bladder TCC.

关 键 词：尿细胞角蛋白 检测 诊断 尿路移行细胞癌 膀胱肿瘤 

分 类 号：R737.1[医药卫生—肿瘤]