外周血、门脉血CEA检测预测结直肠癌转移的临床价值  

Pediction of colorectal cancer metastasis by detection of CEA in peripheral and portal blood

作　　者：郭强[1] 孙劲松[1] 利军[1] 朱长进[1] 孙功平[1] 

机构地区：[1]安徽省巢湖市第一人民医院普外科,238000

出　　处：《蚌埠医学院学报》2003年第6期511-512,共2页Journal of Bengbu Medical College

摘　　要：目的 :检测结直肠癌患者外周血与门脉血癌胚抗原 (CEA)水平 ,并预测结直肠癌转移情况。方法 :采用单克隆抗体放射显影法 ,对 34例结直肠癌患者手术时抽取外周血与门脉血作CEA检测。结果 :18例患者外周血CEA值低于门脉血 (P <0 .0 1) ,16例患者外周血CEA值高于门脉血 (P <0 .0 1)。全部患者术后随访 4～ 2 4个月 ,外周血CEA值低于门脉血的患者 ,结直肠癌转移率 2 2 .2 % ,低于外周血CEA值高于门脉血患者的 6 2 .5 % (P =0 .0 349)。结论 :结直肠癌患者外周血CEA值高于门脉血者转移率高 ,术中检测结果能前瞻性预测结直肠癌的术后转移高危患者 。Objective:To predict the metastasis of colorectal cancer by detecting the carcinoembryonic antigen(CEA) levels in peripheral and portal blood.Methods:The CEA in the peripheral and portal blood of 34 patients with colorectal cancer was detected by monoclonal antibody radioimmunoimaging.Results:The CEA level in the peripheral blood of 18 patients with colorectal cancer was much lower than that in the portal blood( P <0.01),and the CEA level in the peripheral blood of 16 cases was much higher than that in the portal blood( P <0.01).All patients were followed up for 4 to 24 months.The occurrence rate of metastasis was 22.2% in patients whose CEA in peripheral blood was lower than that in portal blood.The rate of merastasis was 62.5% in patients whose CEA in peripheral blood was higher than that in portal blood.The difference was significant( P = 0.034 9 ).Conclusions:The rate of postoperative metastasis is higher in patients with colorectal cancer whose CEA level in peripheral blood is higher than that in portal blood.Detection of CEA is helpful to prospectively predict neoplasm metastasis of colorectal cancer in the early stage of postoperation.

关 键 词：结肠肿瘤 肿瘤转移 癌胚抗原 外周/门静脉血 预测 

分 类 号：R735.35[医药卫生—肿瘤]