s-三唑[3,4-b]-1,3,4-噻二嗪衍生物抑菌活性研究  

STUDY ON ANTIBACTERIA ACTIVITY OF S-THIAZOLO-[3,4-b]-1,3, 4-THIADIAZINE DERIVATIVES AND STRUCTURE ACTIVITY RELATIONSHIPS

作　　者：张琪[1] 王勤[1] 韩寅[1] 何永刚[2] 惠新平[2] 

机构地区：[1]兰州大学生命科学学院,兰州730000 [2]兰州大学应用有机国家重点实验室,兰州730000

出　　处：《微生物学通报》2003年第5期61-64,共4页Microbiology China

基　　金：甘肃省科技攻关项目 (No GS0 2 2 A4 3 136 )

摘　　要：为了探讨新合成的s 三唑 [3,4 b] 1 ,3 ,4 噻二嗪衍生物的抗菌活性 ,对 1 0种s 三唑 [3,4 b] 1 ,3,4 噻二嗪衍生物进行了抑菌实验测定 ,对其中 4种进行了MIC、生长曲线测定及构效关系的探讨。结果表明 ,该系列s 三唑 [3 ,4 b] 1 ,3 ,4 噻二嗪衍生物对受试菌株均有一定的抑制作用 ,其中TSQ5、TSQ6、ISO2和ISO3作用较为明显 。Ten derivatives of thiadiazine that had not been found in literature w ere designed and synthesized. To study their antibacteria activity, we tested t h eir activity against three bacteria in dosage-dependent and time-dependent man ne r. TSQ5,TSQ6, ISO2 and ISO3 showed significant activity, and structure activity relationships showed that chlorine substituent was very important for their anti bacteria activity.

关 键 词：s-三唑[3 4-b]-1 3 4-噻二嗪 抑菌活性 构效关系 

分 类 号：S859[农业科学—临床兽医学]