低能量氦-氖激光血管内照射对急性脑梗死患者血浆内皮素的影响  

Effect of intravenous irradiation of low energy He-Ne laser on levels of endothelin in patients with acute cerebral infarction

作　　者：陈红兵[1] 孙圣刚[1] 童萼塘[1] 

机构地区：[1]华中科技大学同济医学院附属协和医院神经内科,武汉430022

出　　处：《中华物理医学与康复杂志》2003年第11期675-677,共3页Chinese Journal of Physical Medicine and Rehabilitation

摘　　要：目的　探讨低能量氦 氖激光血管内照射 (ILIB)对急性脑梗死患者血浆内皮素 (ET)的影响。方法　 85例急性脑梗死患者随机分为ILIB治疗组与常规治疗组 ,采用放免法分别测定 2组患者治疗前及治疗后的血浆ET水平 ,将同时来院查体的健康老年人 3 9例作为正常对照组 ,并用同种方法测定血浆ET水平。结果　ILIB治疗组 48例 ,治愈 11例 ,显效 2 6例 ,有效 8例 ,无效 3例 ,总有效率 93 .75%。常规治疗组 3 7例 ,治愈 4例 ,显效 14例 ,有效 12例 ,无效 7例 ,总有效率 81.0 8%。 2组比较 ,差异有显著性 (P <0 .0 5)。急性脑梗死患者血浆ET水平明显高于正常对照组 (P <0 .0 1) ,治疗 10d后 ,ILIB组血浆ET水平下降明显 ,由(69 .0 1± 10 .3 1)ng/ml降至 (52 .3 2± 8.43 )ng/ml(P <0 .0 1) ,并趋于正常 (P >0 .0 5) ,常规治疗组由 (67.43±11.42 ) pg/ml降至 (59.93± 10 .56) pg/ml ,但仍明显高于正常对照组 (P <0 .0 5)。治疗 2 0d后 ,2组ET水平均下降 ,ILIB治疗组降至 (50 .0 9± 7.2 4) pg/ml,常规治疗组降至 (51.3 6± 8.2 1) pg/ml ,并均趋于正常 (P >0 .0 5)。结论　ILIB能降低急性脑梗死患者血浆ET的水平 。Objective To explore the effect of intra ve nous irradiation of low energy He-Ne laser on plasma endothelin(ET) levels in p atients with acute cerebral infarction (ACI). Methods Eighty-five patients with ACI were randomly divided into two groups: In group s I, the patients were treated with low energy He-Ne laser intravenous irradiat ion combined with conventional treatment (group ILIB);In group II, the patients were only received the conventional treatment (conventional control group). The levels of plasmal ET were measured using radioimmunoassay before and 10, 20 days after the treatment, simultaneously 39 healthy subjects were examined for ET le vels and served as the normal control group. Results Before treatment, the plasmal ET level of ACI was significantly higher than th at of normal control group ( P <0.01). After 10 days of treatment, the ET lev el in group ILIB was decreased significantly, from 69.01±10.31ng/ml to 52.32±8 .43ng/ml ( P <0.01), but the ET level in the conventional control group was de creased only from 67.43±11.42ng/ml to 59.93±10.56ng/ml. After 20 days of treat ment, the ET levels in group ILIB and in conventional control group were decreas ed nearly to normal level ( P >0.05). ConclusionIt was suggested that intravenous irradiation therapy with low energy He-Ne laser could inhibit ET release and facilitate the recovery of ACI patients.

关 键 词：低能量氦—氖激光血管内照射 急性脑梗死 血浆 内皮素 影响 

分 类 号：R743.33[医药卫生—神经病学与精神病学]