进展性脑梗死溶栓临床时效与安全性分析  

Clinical effect and safty of intravenous thrombolysis with urokinase in patients with progressive ischaemic stroke

作　　者：张镛[1] 李春霞[1] 李松奎 王维宝 苏维展 

机构地区：[1]山东省立医院,山东济南250021 [2]临沂市中医院 [3]淄博市淄川区医院 [4]宁阳县人民医院

出　　处：《山东医药》2003年第25期1-3,共3页Shandong Medical Journal

摘　　要：目的　探讨尿激酶 (UK)静脉溶栓治疗进展性脑梗死的疗效 ,分析其时效和安全性。方法　对发病6小时后病情继续发展的 111例急性脑梗死患者分为 U K组和对照组治疗。结果　 UK组疗效高于对照组 (P <0 .0 5 )。治疗组治疗后 1小时、14天评分改善明显 ,病情进展趋势控制 (P <0 .0 5 )。首次发病至溶栓的间隔时程与临床疗效未见相关性。UK组有出血倾向 5例 (8.2 % ) ;对照组 1例 (2 % )。结论　静脉应用 U K治疗进展性急性脑梗死是可行的 ,其疗效与基础病变有关 。Objective To assess the feasibility,clinical effect and safety of intravenous thrombolysis with urokinase(UK) in patients with progressive cerebral infarction.Methods 111 patients overrun 6h after an first ischemic onset were randomly divided into UK group and control group.61 patients were treated with intravenous UK and low molecule weight heparin,and 50 patients were treated with defibrase as controls.Results Two groups improved significantly after treatment,but clinical effect in UK group was superior to that in the control group(P<0.05).Grade of 1h and 14d in UK group improved obviously,and this tendency maintained to 14d(P<0.05).No correlation with clinical curative effect and interval between first onset and thrombolysis were observed.Hemorrhage complication occured in 5 cases of UK group and 1 case of control group,but no one died.Conclusions Intravenous thrombolysis with UK is feasible in admitted progressive cerebral infarction,and it's efficacy is related to the fundamental pathological mechanisms.Treatment time window of 6h or 12h interval restriction after first onset is still approved,and it is different to cerebral infarction with single course of disease.

关 键 词：进展性脑梗死 尿激酶 静脉溶栓 治疗 疗效 临床时效 安全性 

分 类 号：R743.33[医药卫生—神经病学与精神病学]