食管鳞癌乙型肝炎病毒表达及与Rb、C-myc的关系  

The Expression of HBV and Its Relationship with Rb and C - myc Expression in Esophageal Squamous Carcinoma

作　　者：陈正言[1] 朱东兵[1] 朱小平[1] 蔡美如[1] 

机构地区：[1]江苏省如皋市人民医院,江苏如皋226500

出　　处：《中国肿瘤》2003年第10期602-605,共4页China Cancer

摘　　要：[目的]探讨乙型肝炎病毒(HBV)与食管鳞癌的关系。[方法]取100例食管鳞癌和60例正常食管或食管炎病人(对照组)的内镜活检标本应用免疫组化法检测HBsAg和HBcAg,检测食管鳞癌抑癌基因Rb和癌基因C鄄myc的表达。两组均作血清HBV标志物检测。[结果]食管鳞癌癌组织和癌旁组织HBsAg和/或HBcAg表达率分别为33%和28%,总表达率42%,明显高于对照组(10%),P<0.01。食管鳞癌癌组织中HBsAg和/或HBcAg表达阳性者Rb和C鄄myc表达阳性率和表达强度等级均明显高于表达阴性者,Rb和C鄄myc表达阳性率分别为84.9%vs59.7%,84.9%vs56.7%,P均<0.05。在癌旁不典型增生中,HBsAg和/或HBcAg表达阳性者与表达阴性者比较,Rb表达阳性率无显著性差异。但表达强度在HBsAg和/或HBcAg表达阳性者明显高于表达阴性者,P<0.05;C鄄myc表达阳性率分别为57.1%vs24.4%,P<0.05,但表达强度无显著性差异。在癌旁正常鳞状上皮HBsAg和/或HBcAg表达阳性者与表达阴性者比较,Rb和C鄄myc表达阳性率和表达强度等级均无显著性差异。HBsAg和/或HBcAg表达与癌的分化程度无关。食管鳞癌病人组织HBsAg和/或HBcAg表达与血清HBsAg阳性一致。[结论]HBV与食管鳞癌发病有关。To investigate the relationship between Hepatitis B virus(HBV)and esophageal squamous cancer.The expression of HBsAg and HBcAg were detected immunohistochemically in endoscopic biopsy specimens of esophageal squamous cancer(100cases)and control group(60cases including normal esophageal mucus membrane and esophagitis).At the same time Rb and C-myc were detected in esophageal cancer.Serum HBV markers were exam-ined in both groups.The expressive rate of HBsAg and/or HBcAg in esophageal carcinoma and surrounding carcinoma was33%and28%respectively.The overall positive expression rate was42%,significantly higher than that in control group(10%)(P<0.05).In carcinoma tissue with HBsAg and/or HBcAg positive expression,the rate and intensity grade of Rb and C-myc expression were significantly higher than that in HBsAg and/or HBcAg negative expression.The rate of Rb and C-myc expression was84.9%vs59.7%,84.9%vs56.7%respectively(P<0.05).In atypical hyperplasia surrounding carcinoma,compared the positive expression of HBsAg and/or HBcAg with the negative,the expressive rate of Rb was71.4%vs43.9%(P>0.05),but the expressive intensity grade in HBsAg and/or HBcAg positive expression was higher than that in negative expression(P<0.05);the expressive rate of C-myc was57.1%vs24.4%respectively(P<0.05).In normal squamous epithelium surrounding carcinoma,the comparison between the positive and negative HBsAg and/or HBcAg,the expressive rate and intensity grade of Rb and C-myc were no difference.The expression of HBsAg and/or HBcAg was not related to the degree of differentiation of esophageal carcinoma.The patients that expressed HBsAg and/or HBcAg in the carcinoma or the surrounding carcinoma of esophageal cancer were consistent with the positive serum HBsAg.[Conclusion]HBV is related to the pathogenesis of esophageal cancer.

关 键 词：乙型肝炎病毒 食管肿瘤 RB C-MYC 

分 类 号：R735.1[医药卫生—肿瘤] R73-3[医药卫生—临床医学]