外周血端粒酶活性和组织多肽特异性抗原联合检测在乳腺癌诊疗中的应用价值  

The Clinic Value of Diagnosis and Treatment of Breast Cancer of the Detection Combining Telomerase Activity with TPS Lever

作　　者：俞军[1] 俞乔[1] 戴美红[1] 何晓松[1] 周晓明[1] 

机构地区：[1]江苏省肿瘤医院科研科,江苏南京210009

出　　处：《河南肿瘤学杂志》2003年第5期332-333,共2页Henan Journal of Oncology

摘　　要：目的　评估外周血端粒酶活性和组织多肽抗原联合检测在乳腺癌患者中的诊疗价值。方法　对 65例乳腺癌患者和 15例乳腺良性病变患者 ,收集外周血单个核细胞 ,应用TRAP -ELISA法检测其端粒酶活性 ;同时对其血清应用ELISA法检测组织多肽特异性抗原的表达情况。结果　外周血端粒酶活性和组织多肽抗原的表达均与乳腺癌淋巴结转移密切相关 (P <0 0 5 ) ,其中 ,外周血端粒酶活性的表达还与癌组织的浸润相关 (P <0 0 1)。结论　外周血端粒酶活性和组织多肽抗原的表达预示着乳腺癌具有较强的转移能力 ,联合检测其活性的表达对患者预后的评估及治疗方案的制定具有重要的意义。Objective To evaluate the expression of telomerase activity and TPS lever in diagnosis and treatment of breast cancer. Methods we have detected telomerase activity and TPS lever of 65 cases of breast cancer by PCR-ELISA and ELISA. Results The expression of telomerase activity and TPS lever were all correlated to tumor metastasis( P <0.05);as well as telomerase activity was correlated to tumor invasion( P <0.01).Conclusions Telomerase activity and TPS lever may be involved in metastasis of breast cancer, the detection combining telomerase activity with TPS lever has its clinic value in evaluation and treatment of breast cancer.

关 键 词：乳腺癌 诊断 治疗 端粒酶 组织多肽 抗原 恶性肿瘤 

分 类 号：R737.9[医药卫生—肿瘤]