CYP1A1基因多态性与急性淋巴细胞白血病的关系  

Relationship between genetic polymorphisms of CYP1A1 and ALL

作　　者：高建平[1] 黄跃东[1] 梁建平[1] 方晓霞 

机构地区：[1]漳州市中医院,福建漳州363000 [2]龙岩第一医院,福建龙岩364000

出　　处：《中国优生与遗传杂志》2003年第5期21-22,24,共3页Chinese Journal of Birth Health & Heredity

摘　　要：目的　探讨CYP1A1基因多态性与急性淋巴细胞白血病 (ALL)遗传易感性的关系。方法　应用PCR -RFLP、ASA技术 ,分析 78例ALL患者和 112例健康人CYP1A1基因多态性 ,比较ALL患者与对照组间频率差异。结果　ALL组CYP1A1MspI基因多态位点 ,各等位基因和基因型频率与对照组比较有显著性差异 (P <0 .0 5 ) ,其中等位基因m2使患ALL的危险度提高了 1.5 4倍 ,m1m2、m2m2基因型使患ALL的危险度分别提高了 2 .2 7倍和 2 .77倍 ;ALL组CYP1A1Ile-Val各等位基因和基因型频率与对照组比较无显著性差异 (P >0 .0 5 )。结论　CYP1A1MspI基因多态可能与ALL的发生有关。Objective: To study the possible relationship between CYP1A1 genetic polymorphisms and susceptibility of acute lymphoblastic leukemia(ALL). Method: 78 cases of ALL and 112 healthy controls of CYP1A1 genetic polymorphisms were analysed with the methods of PCR-RFLP、ASA. The difference of frequency between the patients with ALL and the controls were compared. Result: Among ALL and their matched controls,the frequencies of alleles and genotypes are significantly different with MspI gene polymorphisms (P<0.0 5), the frequency of the m2 allele was significantly higher than that in their matched controls with an odds ratio of 1.54(P<0.05),the frequency of the m1m2 and m2m2 genotypes were significantly higher than those in their matched controls with an odds ratio of 2.27 and 2.77(P<0.05), respectively; No significant differences were found between the frequencies of the Ile-Val alleles and genotypes of patients with ALL and the matched controls(P>0.05).Conclusion: The CYP1A1 MspI gene polymorphisms might be associated with the occurrence of All.

关 键 词：急性淋巴细胞白血病 细胞色素P4501A1基因 多态现象 

分 类 号：R733.71[医药卫生—肿瘤]