原发于女性生殖系统的非霍奇金淋巴瘤28例临床研究  

Primary non-Hodgkin lymphoma in the female genital system:a report of 28 cases

作　　者：胡毅[1] 冯奉仪[1] 张频[1] 周立强[1] 章文华[1] 王奇璐[1] 

机构地区：[1]中国医学科学院中国协和医科大学肿瘤研究所肿瘤医院内科,北京100021

出　　处：《中华肿瘤杂志》2003年第5期486-489,共4页Chinese Journal of Oncology

摘　　要：目的　探讨原发于女性生殖系统的非霍奇金淋巴瘤 (PFGSL)的临床特征、治疗方法及预后的影响因素。方法　回顾性分析 2 8例PFGSL的临床资料 ,分析其临床分期、恶性程度、病理类型、治疗方法及其与预后的关系 ,运用SPSS10 .0软件包分析其预后的影响因素。结果　 2 8例PFGSL患者中位年龄 4 4岁 ,病变多累及子宫、宫颈、卵巢和阴道等部位。B细胞来源 2 0例 ,T细胞来源 4例 ,来源不明 4例。依国际工作分类 (IWF) ,中度恶性占 6 6 .7%。按AnArbor分期 ,ⅠE 期和Ⅳ期各占4 2 .9%。ⅡE 期占 10 .7% ,ⅢE 期占 3.6 %。国际预后指数 (IPI)低危 10例 ,低中危 9例 ,中高危 3例 ,高危 6例。全组患者中位生存期 (MST) 2年 ,5年生存率 39.3%。治疗多采用综合治疗 ,各综合治疗模式对生存率的影响差异无显著性 (P =0 .2 5 5 4 )。发病部位、分期、IWF及IPI不同 ,其生存期差异有显著性。结论　PFGSL治疗应采用以化疗为主的综合治疗 ;发病部位、分期、IFW及IPI是预后的影响因素。Objective To evaluate the clinical characteristics, results of treatment, and prognostic factors of patients diagnosed as having primary female genital system lymphoma(PFGSL ). Methods Twenty-eight cases of PFGSL were retrospectively surveyed and the clinical data of the patients were analyzed by statistic software package of SPSS10.0 for relation between clinical stage ,grade, pathologic feature, treatment and prognosis. Results The median age was 44 in the cohort. It mainly involved cervix uterus, ovary and vulva .The disease had a broad range of pathologic type and 20 patients were diagnosed as suffening from B-cell by immunophenotyping, 4 patients were diagnosed as T-cell and 4 patients lesions were indefinite. According to International Working Formulation(IWF), 66.7% belonged to the intermediate-grade. The Ann Arbor stage included: Stage Ⅰ_E-12 pts(42.86%), Stage Ⅱ_E-3 pts(10.7%), Stage Ⅲ_E-1 pts(3.6%) and Stage Ⅳ-12 pts(42.86%). According to International Prognostic Index (IPI ), 10 were low risk, 9 low-medium risk, 3 medium-high risk and 6 high risk . The median follow-up of the surviving patients was 2.0 years (range:3 months-17years), The 5-year overall survival rate was 39.3%. Most patients were given comprehensive treatment without any mode showing significant advantage over the others in survival(P=0.2554) . The involved organs, Ann Arbor stage, IWF and also IPI were significant prognostic factors for survival . Conclusion The management of PFGSL should be based on comprehensive treatment including chemotherapy as the chief means. The significant prognostic factors of survival is Ann Arbor stage, IPI , IWF and the kind of involved organs.

关 键 词：原发于女性生殖系统 非霍奇金淋巴瘤 临床研究 预后 

分 类 号：R737.3[医药卫生—肿瘤]