短期新辅助内分泌治疗对前列腺癌神经内分泌分化的影响  

Impact of short-term neoadjuvant hormonal treatment on neuroendocrine differentiation in prostate carcinoma

作　　者：李贵忠[1] 曾荔[1] 张军[1] 袁亦铭[1] 杨新宇[1] 王静华[1] 那彦群[1] 郭应禄[1] 

机构地区：[1]北京大学第一医院泌尿外科北京大学泌尿外科研究所,100034

出　　处：《中华肿瘤杂志》2003年第5期493-495,共3页Chinese Journal of Oncology

摘　　要：目的　探讨短期新辅助内分泌治疗对前列腺癌神经内分泌分化的影响 ,以及神经内分泌分化程度和肿瘤退化程度的关系。方法　采用嗜铬素A(ChA)和 5 羟色胺特异性免疫抗体作为神经内分泌细胞标记物 ,分析 18例前列腺癌患者内分泌治疗前后神经内分泌分化程度的差异。结果治疗前后 ,癌灶内神经内分泌肿瘤细胞数分别为 3.2× 10 5/ μm2 [(0～ 5 .7)× 10 5/ μm2 ]和 2 .3× 10 5/ μm2[(0～ 6 .6 )× 10 5/ μm2 ],差异无显著性 (P >0 .0 5 )。治疗前后神经内分泌肿瘤细胞百分比分别为7.0 % (0 %～ 14 .9% )和 4 .5 % (0 %～ 13.1% ) ,差异无显著性 (P >0 .0 5 )。 6例肿瘤中重度退化者与12例无退化或轻微退化者相比 ,癌灶内神经内分泌肿瘤细胞数差异无显著性 (P >0 .0 5 )。结论　短期新辅助内分泌治疗未导致明显前列腺癌神经内分泌细胞克隆增殖 ,治疗后肿瘤的退化程度和神经内分泌分化程度无明显相关性。Objective To study the impact of short-term neoadjuvant hormonal treatment on neuroendocrine (NE) differentiation and the relation of NE differentiation and tumor regression. Methods The radical prostatectomy specimens and the biopsy specimens of the same 18 patients with prostate cancer were compared. The effect of hormonal treatment on NE-differentiation was evaluated by specific antibodies against chromogranin A (ChA) and serotonin (5-HT). Results The ChA-positive cell count was 3.2×10 -5 /μm 2 [(0- 5.7) ×10 -5 /μm 2]before hormonal treatment and 2.3×10 -5 μm 2[(0-6.6)×10 -5 /μm 2] afterward (P>0.05). For the proportion of NE-positive tumor, it was 7.0%(0%-14.9%)and 4.5%(0%-13.1%) (P>0.05). No correlation existed between NE-differentiation and the neoadjuvant hormonal treatment. The NE cell density did not differ significantly between 12 non-/slightly regressive tumor foci and 6 highly regressive ones (P>0.05). Conclusion Short-term neodjuvant hormonal therapy does not induce clonal propagation of NE cells. The degree of tumor regression following short-term neoadjuvant hormonal therapy is not correlated with the NE differentiation.

关 键 词：内分泌治疗 前列腺癌 神经内分泌分化 影响 嗜铬素A 5-羟色胺 特异性免疫抗体 

分 类 号：R737.25[医药卫生—肿瘤]