谷胱甘肽硫转移酶Mul-1(GSTM1)基因多态性与肺癌易感性关系的研究  

The Relation ship Between Polymorphism of GSTM1 and Susceptibility to Lung Cancer

作　　者：冼雪珍[1] 陈思东[1] 汪保国[1] 

机构地区：[1]广东药学院流行病学教研室,中国广东广州510224

出　　处：《实用预防医学》2003年第5期635-637,共3页Practical Preventive Medicine

基　　金：广州市重点攻关项目 (JB0 0 0 4 4 80 78)

摘　　要：目的　探讨中国汉族广东人群中谷胱甘肽硫转移酶 Mul- 1(GSTM1)基因缺失及吸烟与肺癌易感性的关系。　方法　采用病例 -对照研究方法 ,应用 PCR技术检测 91例肺癌患者、138例对照的 GSTM1基因多态性。　结果　GSTM1基因缺失在肺癌组和对照组中的频率分别为 6 1.5 %和 5 2 .9% ,OR=1.38(0 .80～ 2 .38)差异无统计学意义 (P>0 .0 5 ) ,与吸烟联合分析时发现 GSTM1基因缺失的 OR值为 3.0 7,比单纯吸烟对肺癌的 OR值 (1.87)大 (P<0 .0 1)。　结论　Objective To evaluate the relationship between GSTM1 genetic polymorphism and lung cancer susceptibility among Cantonese in China. Methods In a case-control study, PCR was used to identify the genotypes of GSTM1 in 91 lung cancer cases and 138 controls. Result Between the case group and the control group, GSTM1 Polymorphism did not show frequency distribution differences(61.5%, n=91; 52.9%,n=138,P>0 05),OR=1 38(0.80~2.38), but the OR of GSTM1 null genotype among smokers in the case group(3.07) is higher than that of only smokers(1.87)(P<0.01). Conclusion GSTM1 null genotype and smoking is likely to coenhance the individual's susceptibility to lung cancer.

关 键 词：肺癌 遗传多态性 易感性 病例对照 谷胱甘肽硫转移酶 

分 类 号：Q555[生物学—生物化学] R734.2[医药卫生—肿瘤]