中国职业性膀胱癌的生物学监测及其意义  

The biological monitoring and its significance in the diagnosis of occupational bladder cancer

作　　者：夏溟[1] 臧美孚[1] 李汉忠[1] 毕文芳[2] 尹松年[2] 

机构地区：[1]北京协和医院泌尿外科,100730 [2]中国预防医学科学院劳动卫生与职业病研究所

出　　处：《中华泌尿外科杂志》2003年第10期684-685,共2页Chinese Journal of Urology

摘　　要：目的　早期诊断中国联苯胺作业工人职业性膀胱癌。　方法　根据流行病学调查原则 ,对 1796名联苯胺作业工人 ,采用巴氏细胞学检查和定量荧光显微影像分析 (QFIA)法检查尿脱落细胞DNA ,G Actin(细胞骨架蛋白 )和M 344肿瘤相关抗原 ,结合临床检查分析。　结果　 1796名人员中发现膀胱癌 30例 ,肾盂癌 1例 ,占 1.73%。移行细胞癌病理分级Ⅰ级 3例 ,Ⅱ级 10例 ,Ⅲ级18例。高危险度者发展到临床确诊平均历时 18个月。职业性膀胱癌发病潜伏期 5～ 30年 ,平均 2 1.2年。　结论　巴氏细胞学检查和QFIA法有利于发现潜在发生职业性膀胱癌的高危人群、早期诊断职业性膀胱癌。Objective To make early diagnosis of occupational bladder cancer in benzine-exposured worker in China. Methods An epidemicological investigation was made for a total of 1 796 benzidine-exposured worker.All the urine sample were tested for cytology,DNA G-Actin and M344 tumor associated antigen by PaP and QFIA methods.Clinical studies were then carried out for the high risk workers. Results 30 cases of bladder cancer and 1 pelvic cancer were found(1.73%),all of which were transitional cell carcinoma.There were 3 grade Ⅰ tumors,10 grade Ⅱ,18 grade Ⅲ.For the high risk workers,the time elapsed for the occurrence of clinical cancer was 18 months in average and the average patent time of occupational bladder cancer was 21.2 years (5～30 years). Conclusions Pap cytology and QFIA are beneficial to the early diagnosis and screening of occupational bladder cancer.

关 键 词：中国 职业性膀胱癌 生物学监测 联苯胺作业工人 

分 类 号：R737.14[医药卫生—肿瘤]