组织多肽特异性抗原检测在卵巢癌诊断和治疗中的应用价值  

Value of TPS in Diagnosis and treatment of Ovarian Cancer

作　　者：陈燕[1] 谢榕[1] 郭俊英[1] 黄建英[1] 胡敏华[1] 

机构地区：[1]福建省肿瘤医院,350014

出　　处：《实用癌症杂志》2003年第5期522-524,共3页The Practical Journal of Cancer

摘　　要：目的　探讨组织多肽特异性抗原 (TPS)在卵巢癌诊断和治疗中的应用价值。方法　对 96例卵巢癌患者 (初诊未治组 3 6例 ,治疗有效组 3 5例 ,复发转移组 2 5例 )和 3 3例妇科良性疾病患者 ,采用ELISA法和EIA法分别检测血清TPS及CA12 5水平。结果　TPS对卵巢癌初诊的特异性、阳性预测值 (PV+ )及准确性与CA 12 5无显著性差异 (P >0 .0 5 ) ,而灵敏度、阴性预测值 (PV-)显著低于CA 12 5 (P <0 .0 5 ) ,两者联合检测可显著提高卵巢癌诊断准确性 (P <0 .0 5 )。Ⅲ +Ⅳ期卵巢癌患者血清TPS和CA12 5平均水平及阳性率均显著高于Ⅰ +Ⅱ期 (P <0 .0 5 )。治疗有效组TPS和CA12 5水平显著低于初诊未治组 ,而复发转移组TPS水平 10 0 .0 %升高。结论　TPS的检测有助于卵巢癌复发、转移的诊断 ,可用于其疗效观察、病情追踪、监测复发及预后判断 ,与CA12 5联合检测 。Objective To determine the clinical value of the serum tissue polypeptide antigen(TPS) in diagnosis and treatment of ovarian cancer.Methods The levels of serum TPS and CA125 were detected by ELISA and EIA in 96 cases with ovarian cancer(including 36 cases before treatment,35 with CR+PR+SD,25 with relapse or metastasis) and 33 control cases with ovarian benign disease.Results The specificity,PV +,and the accuracy were not significantly different between TPS and CA125 in ovarian cancer(P>0.05),but the sensitivity and PV - of TPS was significantly lower than those of CA125(P<0.05).A combination examination of TPS and CA125 increased the diagnostic accuracy(P<0.05).The positive rate and the level of TPS and CA125 in ovarian cancer at stage Ⅲ+Ⅳ were significantly higher than in those at stage Ⅰ+Ⅱ(P<0.05).The level of TPS and CA125 in ovarian cancer with CR+PR+SD was significantly lower than in those before treatment.And the level of TPS rose in the patients with relapse and metastasis.Conclusion The neoplastic marker TPS is helpful for diagnosis of ovarian cancer with relapse and metastasis.It can also used in assessing the treatment effect and prognosis of the ovarian cancer.Combination examination of TPS and CA125 in ovarian cancer patients can increase the diagnostic accuracy.

关 键 词：组织多肽特异性抗原 检测 卵巢癌 诊断 治疗 

分 类 号：R737.31[医药卫生—肿瘤]