穴位对氨茶碱经皮吸收的影响  

Effect of the acupoint on percutaneous absorption of aminophylline

作　　者：刘建平[1] 徐斌[2] 杨彬[1] 

机构地区：[1]中国药科大学药物制剂研究所,南京210009 [2]南京中医药大学针灸研究所

出　　处：《中国针灸》2003年第6期355-357,共3页Chinese Acupuncture & Moxibustion

基　　金：江苏省自然科学基金资助项目 (编号 :BK2 0 0 10 81);江苏省针灸学重点实验室开放基金项目(编号 :K9850 )

摘　　要：目的 :研究不同穴位皮肤经皮吸收药物的作用差异。方法 :观察组分别选择中医治疗支气管哮喘的常用穴———“肺俞”和“膻中”为用药部位 ;对照组以背部非穴位点为用药部位 ,测定氨茶碱贴剂给药后皮肤穴位电阻和血药浓度。结果 :与对照组相比 ,“肺俞”和“膻中”给药后皮肤电阻较低 ,氨茶碱透皮浓度较高 ,差异均有非常显著性意义 (P <0 0 1 )。结论 :“肺俞”和“膻中”Objective To compare effects of drug application at different acupoints. Methods In the observation group, Feishu (BL 13) and Danzhong (CV 17), commonly used acupoints for treatment of bronchial asthma, were selected for application of aminophylline; and in the control group non acupoints on the back were selected for application of the drug. The skin electric resistance of acupoints and the content of blood aminophylline were determined after application of aminophylline plaster. Results The skin resistance was lower on 'Feishu'and 'Danzhong', and the blood content of aminophylline was higher in the observation group as compared with the control group, with very significant differences (both P <0 01). Conclusion Application of aminophylline at 'Feishu' and 'Danzhong' is beneficial to its percutaneous absorption.

关 键 词：穴位 氨茶碱 经皮吸收 影响 支气管哮喘 肺俞 膻中 血药浓度 

分 类 号：R224.2[医药卫生—中医基础理论]