封闭群草原兔尾鼠正常血液生化指标的测定  

Determination of Normal Blood Biochemical Parameters of a Closed Colony of Lagurus lagurus

作　　者：张东辉[1] 许永华[1] 是文辉[1] 伏建峰[2] 蒋卫[3] 张兰英[3] 于万海[4] 

机构地区：[1]兰州军区乌鲁木齐总医院动物实验科,乌鲁木齐830000 [2]兰州军区乌鲁木齐总医院检验科,乌鲁木齐830000 [3]新疆地方病防治研究所,乌鲁木齐830002 [4]新疆军区军犬训练队,乌鲁木齐830002

出　　处：《动物学杂志》2003年第5期95-98,共4页Chinese Journal of Zoology

基　　金：国家科技部"九五"攻关项目 (No.TJ99LA0 1)

摘　　要：利用雅培 (AEROSET)全自动血液生化测定仪对封闭群草原兔尾鼠 2 3项血液正常生化指标进行了测定。与昆明小鼠、BALB c nu小鼠、Wistar大鼠、人的正常值相比较 ,该种实验动物血液正常生化指标具有以下特点 :①总蛋白 (TPROT)、白蛋白 (ALB)、球蛋白 (GLOB)、总胆红素 (TBILI)、直接胆红素 (DBILI)、间接胆红素 (IBILI)、尿素氮 (UREA)、二氧化碳 (CO2 )、甘油三脂 (TG)、胆固醇 (CHOL)、钠 (Na)、氯 (Cl)、镁(Mg)、总钙 (TCA)的测定值 ,五者间无显著性差异 (P >0 0 5 ) ;②封闭群草原兔尾鼠与昆明小鼠相比 ,谷草转氨酶 (AST)、谷丙转氨酶 (ALT)、糖 (GLU)、钾 (K)、磷 (P3 + )存在显著性差异 (P <0 0 1或P <0 0 5 ) ;③封闭群草原兔尾鼠与BALB c nu小鼠相比 ,谷草转氨酶 (AST)、谷丙转氨酶 (ALT)、碱性磷酸酶 (ALP)、糖 (GLU)测定值 ,存在显著性差异 (P <0 0 1或P <0 0 5 ) ;④封闭群草原兔尾鼠与Wistar大鼠相比 ,谷草转氨酶、谷丙转氨酶、钾、糖测定值 ,存在显著性差异 (P <0 0 1或P <0 0 5 ) ;⑤封闭群草原兔尾鼠与人相比 ,谷草转氨酶、谷丙转氨酶、碱性磷酸酶、乳酸脱氢酶 (LDH)、肌肝 (CREAT)、尿酸 (UA)、钾 (K)存在显著性差异 (P <0 0 1或P <0 0 5 )。结果表明In this article, 23 blood biochemical parameters of a Lagurus lagurus closed colony were determinated using an AEROSET auto blood biochemical radiometer. Compared with KM mice, BALB/c-nu mice, Wistar rats and normal human blood parameters,the blood biochemical parameters of this new experimental animal have the following characteristics:1. The parameters of TPROT, ALB, GLOB, TBILI, DBILI, IBILI, UREA, CO 2, TG, CHOL, Na, Cl, Mg, TCA did not differ between the L.lagurus closed colony, KM mice, BALB/c-nu mice, Wistar rat and humans (P>0 05). 2. The parameters of AST, ALT, GLU, K, P 3+ differed between the L.lagurus closed colony and KM mice (P<0 01 or P<0 05).3. The parameters of AST, ALT, ALP,GLU differed between the L.lagurus closed colony and BALB/c-nu mice (P<0 01 or P<0 05). 4. The parameters of AST, ALT, K, GLU differed between the L.lagurus closed colony and Wistar rats (P<0 01 or P<0 05).5. The parameters of AST, ALT, ALP, LDH, CREAT, UA, K differed between the L.lagurus closed colony and humans (P<0 01 or P<0 05).The results show: this animal may become a model for studying changes in blood biochemical parameters and metabolism in humans. In addition,we can refer to the experience of developing KM mice, BALB/c-nu mice and Wistar rats to develop this new experimental animal as soon as possible.

关 键 词：草原兔尾鼠 血液生化指标 昆明小鼠 实验动物 

分 类 号：R-332[医药卫生]