不同分子量壳低聚糖抗菌作用的研究  

Study on antibacterial effects of chitooligosacchrides with different molecular weight

作　　者：孙晓文[1] 金蕴[2] 

机构地区：[1]浙江大学医学院附属邵逸夫医院,浙江杭州310016 [2]浙江大学医学院附属妇幼保健院,浙江杭州310016

出　　处：《中国现代应用药学》2003年第5期351-353,共3页Chinese Journal of Modern Applied Pharmacy

摘　　要：目的　研究不同分子量的壳低聚糖抗金黄色葡萄球菌、大肠杆菌的能力及其最低杀菌浓度。方法　分别测定及比较加有壳低聚糖的培养基及空白培养基的菌浓。结果　不同分子量、不同浓度的壳低聚糖的抗菌作用强弱不一 ,同一规格壳低聚糖对金黄色葡萄球菌、大肠杆菌的作用强度不同。结论　壳低聚糖对金黄色葡萄球菌的抗菌作用随分子量的减小而增加 ,随浓度的增加而增加 ,对大肠杆菌作用很不明显 ,且无规律可寻。OBJECTIVE To study the antibacterial effects of chitooligosacchrides with different molecular weight (mol wt ) to St . aureus and E .coli ,Calculate the MICS. METHOD Measured the bacterial concentration in culture media with or without chitooligosacchride.RESULTS The chitooligosacchrides with different mol.wt and in different concentration varied in antibacterial effects. The intensity of effects upon St. aureus and E. coli were also different. CONCLUSION The antibacterial effect of chitooligosacchrides upon St. aureus become stronger as their mol .wt and concentrations increase. The actions upon E.coli are not obvious and no regularities can be drawn..

关 键 词：壳低聚糖 纤维素酶 金黄色葡萄球菌 大肠杆菌 

分 类 号：R282[医药卫生—中药学] R965[医药卫生—中医学]