奥曲肽治疗原发性肝癌并发上消化道出血止血疗效观察  

Therapeutic Effect of Octreotide on Patients with Primary Hepatic Carcinoma Combined with UGH

作　　者：李权[1] 李艳[1] 

机构地区：[1]湖北省新华医院,武汉430015

出　　处：《中国药师》2003年第11期727-727,729,共2页China Pharmacist

摘　　要：目的:观察奥曲肽治疗原发性肝癌并发上消化道出血的疗效。方法:47例原发性肝癌并发上消化道出血随机分为两组,治疗组25例用奥曲肽治疗,对照组22例用垂体后叶素治疗,观察并比较两组的疗效、止血时间、输血量。结果:治疗组总有效率为84％,对照组总有效率为45.4％,两组比较有显著差异(x^2=7.74,P<0.01)。治疗组的止血时间(36±14)h显著少于对照组(96±18)h,P<0.01)。治疗组的平均输血量明显少于对照组(431±56)ml对(782±8)ml,P<0.01)。结论:奥曲肽止血作用迅速、可靠,为治疗肝癌并发上消化道出血的首选药物。Objective: To investigate the effect of octreotide on patients with primary liver carcinoma combined with UGH. Method: 47 in-patients with primary hepatic carcinoma combined with upper gastrointestinal hemorrhaqe (UGH) were divided into two groups randomly, 25 cases were given octreotide, 22 cases as controlled group, which was given pituitrin. The therapeutic effect, haemostasis time and volume of blood transfusion were observed and compared in both groups. Result: The effective rate was 84% in therapeutic group, 45.4% in controlled group. There was significant difference between two group( χ~2= 7.74, P<0.01 ). Haemostasis time was lower significantly in therapeutic group than that in controlled group[ (36±14)hours vs (96±18) hours], P<0.01, so did the volume of blood transfusion[ (431±56)ml vs (782±80)ml], P<0.01. Conclusion: The hemostasis action of octreotide is rapid and reliable, and octreotide is the first selection in treating patients with hepatic carcinoma combined with UGH.

关 键 词：原发性肝癌 上消化道出血 奥曲肽 治疗 疗效 

分 类 号：R573.2[医药卫生—消化系统] R735.7[医药卫生—内科学]