体力活动与乳腺癌发生的关系  

Relationship between Physical Activity and Breast Cancer Risk in China

作　　者：张子豹[1,2] 高尔生 武俊青 De-kun LI 

机构地区：[1]上海市计划生育科研所流行病学室,上海200032 [2]上诲市计划生育科研所流行病学室,上海200032 [3]Division of Research,Kaiser Foundation Research Institute Oakland,CA,美国

出　　处：《生殖与避孕》2003年第5期291-298,共8页Reproduction and Contraception

基　　金：中国国家自然科学基金39770659;美国国立卫生研究院R01-CA71777资助

摘　　要：目的:评估体力活动是否可降低中国妇女乳腺癌发生。材料与方法:本文利用1998年至2001年在上海市区开展的一项以人群为基础的乳腺癌病例对照研究数据,分析妇女既往不同年龄段(13～19岁青春期和近10年成年期)各种体力活动与乳腺癌的关系。在上海市共招收1 495名合格的乳腺癌病例和1 573名年龄频数匹配的全人群随机对照,应答率分别为95.1％和87.7％,在研究对象家中进行结构式问卷调查。结果:对可能的混杂因素校正后,发现青春期和成年期体育锻炼活动均能降低乳腺癌发生,每周运动量在75％分位数以上的妇女OR值分别为0.83(0.66～1.03)和0.64(0.46～0.87),趋势性检验的P值分别为0.040和0.002。两个年龄段做家务、骑自行车和成年期步行均与乳腺癌无关,但青春期较多步行可减少乳腺癌发生。另外未发现职业体力活动与乳腺癌有明显联系。最后对体育锻炼和日常生活体力活动的综合分析发现,只有成年期的体力活动具有独立的保护作用。结论:较多体力活动可降低中国妇女乳腺癌的发生,但仅成年期体力活动具有独立作用。Objective To investigate whether physical activity in adolescence and adulthood could reduce breast cancer risk among the Chinese women. Materials & Methods: This population-based case-control study was conducted between 1998 and 2001 in urban areas of Shanghai. In-person interviews were completed with 1495 breast cancer cases and 1573 age-matched controls who were randomly selected from the general population, with response rates of 95.1% and 87.7% respectively. Physical activity from exercise and sports doing housework and transportation (walking and cycling) was assessed in adolescence (13～19 years) and adulthood (last 10 years). Results: After adjusting for potential confounding factors, the resuits showed evidence that exercise in adolescence and adulthood could reduce breast cancer risk, with odds ratio (OR) and 95% confidence interval (CI) as 0.83 (0.66～1.03) and 0.64 (0.46～0.87) respectively, and with p value for trend as 0.040 and 0.002 respectively. Neither household activity, cycling in the two age periods, and walking in adulthood, nor occupational physical activity was found related with breast cancer risk. However it showed that only physical activity in adulthood were found related with breast cancer risk independently after analyzing exercise and daily activity jointly. Conclusion:These results showed that frequent physical activity could reduce breast cancer risk among Chinese women, but only those in adulthood might decrease breast caner risk independently. Therefore it is suggested that women may reduce their risk of breast cancer by increasing their activity freauency in adulthood.

关 键 词：乳腺癌 体力活动 病例对照研究 危险因素 

分 类 号：R737.9[医药卫生—肿瘤]