卵巢癌微血管密度与血管壁α-平滑肌肌动蛋白的表达及其临床意义  

The microvessel density and expressions of α-smooth muscle actin in ovarian cancers and their clinical significance.

作　　者：刘召芬[1] 孙韵英[1] 孔亚玮[2] 

机构地区：[1]山东省千佛山医院妇产科,济南250014 [2]山东大学生命科学院

出　　处：《现代妇产科进展》2003年第5期373-375,共3页Progress in Obstetrics and Gynecology

摘　　要：目的 :研究卵巢癌微血管密度 (MVD)、血管壁α 平滑肌肌动蛋白 (α SMA)的表达并探讨其临床意义。方法 :通过免疫组化法 ,分别检测 2 1例卵巢良性肿瘤和 35例卵巢癌血管壁平滑肌特异性标志物α SMA和血管内皮细胞特异标志Ⅷ因子的表达 ,计算α SMA表达指数 (α SMA指数 )和MVD。结果 :卵巢癌血管α SMA中、强表达率为 31.4 % (11/ 35 ) ,明显低于良性肿瘤者的 6 1.9% (13/ 2 1)。卵巢癌α SMA指数平均为 0 .4 2± 0 .33,明显低于良性肿瘤者的 0 .72± 0 .38(P <0 .0 1)。卵巢癌的MVD平均为 2 8.2 7± 2 2 .34,良性肿瘤为 12 .5 3± 16 .5 8,两组差异有显著性 (P <0 .0 1)。α SMA表达及MVD均与临床分期及淋巴结转移有关。Ⅲ期和Ⅳ期卵巢癌的α SMA指数明显低于Ⅰ、Ⅱ期者 ;有淋巴结转移的α SMA指数明显低于无转移者。Ⅲ期和Ⅳ期卵巢癌的MVD明显高于Ⅰ、Ⅱ期者 ;有淋巴结转移的MVD明显高于无转移者。结论 :α SMA指数和MVD分别反映肿瘤新生血管的不同方面 ,α SMA指数反映新生血管的结构 ,MVD代表了新生血管的数量 。Objective:To study the expressions of α smooth muscle actin(α SMA) and microvessel density(MVD) in ovarian cancer and their clinical significance.Methods:The expressions of α SMA and factor Ⅷ were measured by immunohistochemical assay in 21 cases of benign ovarian tumor and 35 cases of ovarian cancer.Results:The rate of moderate and strong expressions of α SMA in ovarian cancers was much lower than that in ovarian benign tumor 31.4% vs 61.9%.The average expression index of α SMA was significantly lower in ovarian cancer (0.42±0.33) than that of benign tumor (0.72±0.38) (P<0.01).The ovarian cancers showed much higher MVD(28.27±22.34), compared with that of benign tumors(12.53±16.58)(P<0.01).The expression index of α SMA and MVD were associated with lymphonode metastases and clinical stages of ovarian cancers.Conclusions:The expression index of α SMA may be used as substitute for the maturity of tumor vessels,The expression index of α SMA and MVD reflect different aspects of tumor angiogenesis,the expression index of α SMA reflects the situation of angiogenesis,while MVD is a substitute for the numbers of microvessels in tumors.

关 键 词：卵巢肿瘤 微血管密度 血管平滑肌 Α-平滑肌肌动蛋白 

分 类 号：R737.31[医药卫生—肿瘤]