正常人手运动功能脑皮质定位的研究  

Study on the cortex localization of the hand motor area in normal subjects

作　　者：李东海[1] 龚洪翰[2] 肖香佐[2] 王进华[2] 淦作松[2] 

机构地区：[1]江西医学院第一附属医院脑外科 [2]江西医学院第一附属医院放射二科,江西南昌330006

出　　处：《中国微侵袭神经外科杂志》2003年第5期220-221,共2页Chinese Journal of Minimally Invasive Neurosurgery

基　　金：江西省教育厅赞助课题(F020501)

摘　　要：目的研究正常人手复杂运动时脑皮质的功能定位。方法采用SIEMENS成像系统的EPI-Bolding程序,采集7例受试者运动和静止状态的T1W图像共6个时相,应用相应软件分析得到差异信号图像,与T1W结构图像融合,并进行三维重建。结果7例受试者在执行握拳运动时,对侧皮质中央前回的第一运动区(Broadman4区)均可见明显激活信号,对侧或双侧的补充运动区均有激活信号,2例运动前区激活,3例可见同侧中央前回运动皮质的激活信号。三维重建显示第一运动区的激活信号主要位于对侧中央沟的中外侧,补充运动区的激活信号位于运动前区(Broadman6区)近正中的内侧面。结论正常人手复杂运动时脑皮质运动网络被广泛激活,功能核磁共振的激活信号反映了脑的高级功能活动。s: Objective To investigate the cortical localization of hand complex movement in normal subjects. Methods T1W imaging from six alternating epochs of rest and active by seven subjects were collected with echoplanar imaging bolding sequence on a 1.5T SIEMENS scanner. Differential maps acquired by t-test were added to T1W structure imaging. Results Significant active signal was located in the primary motor area (Broadman 4) of the contralateral precentral gyrus, and contralateral or bilateral supplementary motor area (SMA) was also activated with seven subjects performing grasping movements. Premotor area was activated in two subjects, and motor cortex of ipsilateral precentral gyrus was activated in three cases. Three-dimension reconstruction demonstrated active signal of primary motor area were mostly located at the middle-lateral surface of the contralateral central sulcus, and signal of supplementary area were located at the mesial surface of the premotor area (Broadman 6). Conclusion Cerebral cortical motor network was extensively activated during hand complex movement in normal subjects. Active signal of functional magnetic resonance imaging reflected the activity of brain high function.

关 键 词：正常人 手运动 脑皮质 功能定位 三维重建 神经外科 

分 类 号：R445.2[医药卫生—影像医学与核医学]