脑梗死疾病与血管紧张素转换酶基因多态性的相关性研究  

The relative study of ACE gene polymorphism and the cerebral infarction disease

作　　者：元小冬[1] 王淑娟[1] 高捷[1] 侯秋霞[1] 吴寿岭[1] 裴焕珍[1] 张萍淑[1] 李宏芬[1] 

机构地区：[1]河北省唐山市开滦医院神经内科,河北唐山063000

出　　处：《中风与神经疾病杂志》2003年第5期428-430,共3页Journal of Apoplexy and Nervous Diseases

摘　　要：目的　研究血管紧张素转换酶 (ACE)基因、血管紧张素 受体 型 (AT R)基因多态性和多种危险因素与脑梗死疾病的相关性。方法　采用整群抽样的方法选取唐山开滦矿业集团职工 135 1人。所有样本均清晨空腹抽取静脉血测定其 ACE、AT R基因型及相关生化指标 ,并进行体检和问卷调查 ,然后依据头部 CT或 MRI结果将之分为脑梗死组和对照组。结果　 ACE基因各基因型在脑梗死组和对照组的频率分布及各基因型人群中脑梗死患病率无明显差异 ,AT1R基因 AA基因型频率分布在脑梗死组高于对照组 ,且 AA型人群脑梗死患病率高于其它基因型 ,但两种基因各联合基因型人群中脑梗死患病率无差异。在与脑梗死有关的各种危险因素存在条件下 ,仅不吸烟人群和有高血压患者群中脑梗死组 AT1R基因 AA基因型频率分布高于对照组。L ogistic回归发现脑梗死与 AT1R基因多态性和性别有明显相关性。结论　在具有高血压病的 AT1R的 AA基因型人群发生脑梗死的危险性明显增加 ,说明脑梗死的发病可能是“基因与环境”因素共同作用的结果。Objective To study the relationship between ACE gene polymorphism, ATIR gene polymorphism and many other risk factors for the cerebral infarction. Methods 1351 people from Tangshan Coalmine were chosen with the method of cluster sampling. Face to face interviews were conducted to fill the questionair by trained interviewers. At the same time, based on the results of CT or MRI, the people were divided into two groups: the cerebral infarction group and the control group. The ACE gene, ATIR gene and other biochemical indexed were measured. Results The prevalence of ACE genotype showed no difference between the two groups. The cerebral infarction group had higher prevalence of AA genotype of ATIR gene than control but that of the combined genotype had no difference to the control group. In the cerebral infarction group, those with a history of smoking and hypertension had higher prevalence of AA genotype than others. The logistic analysis showed that cerebral infarction had strong relationship to sex. Conclusion The risk of suffering from cerebral infarction increases obviously for the people with hypertension and AA genotype of ATIR gene. It implies that cerebral infarction is the result of both environmental and genetic factors.

关 键 词：脑梗死 血管紧张素转换酶 基因多态性 血管紧张素Ⅱ受体Ⅰ型 危险因素 

分 类 号：R743.33[医药卫生—神经病学与精神病学] R394[医药卫生—临床医学]