[B10,22-Asp,B25-Tyr-NH2]-去β链C端五肽胰岛素的合成和性质  

Synthesis and Properties of[Des-(B26-B30),(B10,22-Asp, B25-Tyr-NH_2)]-Insulin

作　　者：许英镐[1] 崔大敷 杨海林[1] 朱尚权[1] 

机构地区：[1]中国科学院上海生物化学研究所,上海200031

出　　处：《生物化学杂志》1992年第2期230-233,共4页

基　　金：国家自然科学基金

摘　　要：本文报道了[B10,22-Asp,B25-Tyr-NH2]-去B链羧端五肽胰岛素的制备及其生物活性。结果表明,这一类似物的生物活力比去五肽胰岛素(DPI)的活力高一倍,但却比Gerald所报道的[B10-Asp,B25-Tyr-NH_2]-DPI的活力低很多,说明后者的高活性可能依赖于分子中B22-Arg的存在。The synthesis and properties of [des-(B26-B30),(B10,22-Asp,B25-Tyr-NH2)]-Insulin were described.The activities in vivo and in vitro of this insulin analogue were 2 fold of des-(B26-B30)-insulin,but much lower than that of [des-(B26 -B30),(B10-Asp,B25-Tyr-NH2)]-insulin as reported by Gerald.It was shown that the high activity of [des-(B26-B30),(B10,22-Asp,B25-Tyr-NH2]-insulin might be dependent on B22-Arginine.

关 键 词：胰岛素 合成 生物活力 

分 类 号：TQ467.32[化学工程—制药化工]