The Stability of Endomorphin-1 Solution  

内吗啡肽-1水溶液的稳定性(英文)

作　　者：刘晖[1] 杨顶建[2] 倪京满[1] 王锐[2] 

机构地区：[1]兰州医学院药学系,甘肃兰州730000 [2]兰州大学生命科学学院,甘肃兰州730000

出　　处：《Journal of Chinese Pharmaceutical Sciences》2003年第3期131-134,共4页中国药学（英文版）

摘　　要：Aim To study the most stable pH value of endomorphin-1 solution and toestimate the shelf-life of EM-1 solution. Methods The content of EM-1 in its solution was determinedby HPLC, and stability was studied by accelerated tests. Results The most stable pH value of EM-1solution was observed. By the accelerated tests we obtained the Arrhe-nius relationship and thepharmacokinetic parameters. Conclusion The most stable pH value of EM-1 solution is 4.5 -4.8. Thet_(1/2)(25℃) is 45 d.目的　研究内吗啡肽 1(EM 1)水溶液最稳定pH值及预测EM - 1水溶液室温贮存期。方法　采用HPLC法作为测定方法 ,利用恒温加速实验研究EM 1水溶液的稳定性。结果　绘制出pH =速率图 ,恒温加速实验得到Arrehnius方程及动力学参数。结论　EM 1水溶液最稳定pH值为 4 .5～ 4 .8,预测EM 1室温 ( 2 5℃ )的t1 2 为 4

关 键 词：ENDOMORPHIN-1 most stable pH value accelerated tests HPLC 

分 类 号：R927.11[医药卫生—药学]