Endomorphin-1 is an endogenous opioid peptide that mediates pain relief through interaction with the μ-opioid receptor in the central nervous system. To enhance the metabolic stability of this tetrapeptide, cyclisati...
This work was supported by a grant from the National Natural Science Foundation of China (No. 81070677). Conflict of interest: None.
Background Food composition and style is changing dramatically now, which causes inappropriate secretion of hormones from brain, gastrointestinal and endo-pancreas, may be related to unbalance of glucose in blood. The...
Aim To study the most stable pH value of endomorphin-1 solution and toestimate the shelf-life of EM-1 solution. Methods The content of EM-1 in its solution was determinedby HPLC, and stability was studied by accelerat...
AIM: To study the analgesic effect of endomorphin-1 ( EM-1). METHODS: The experiment was performed in rats and mice to study the analgesic effect of intraperi-(oneal ( ip) injection of EM-1 with tail stimulation-vocal...