P_(53)蛋白在宫颈癌、宫颈上皮内瘤样变及宫颈炎中的表达及意义  

P_(53)expression in cervicttis, cervical intraepithelial neoplasla and carcinoma of the cervix.

作　　者：王晓丽[1] 李明众[1] 姜根明[2] 宋天宝[3] 王梅[1] 任娟[1] 王红梅[1] 

机构地区：[1]西安交通大学第一医院,西安710061 [2]长安大学基础部,西安710054 [3]西安交通大学医学院,西安710061

出　　处：《陕西肿瘤医学》2001年第4期233-235,246,共4页ShanXi Oncology Medicine

摘　　要：目的　探讨P53蛋白在宫颈癌 ,宫颈上皮内瘤样变及宫颈炎中的表达及意义。方法　采用免疫组化SP法检测了P53蛋白在 8例慢性宫颈炎 ,10例宫颈上皮内瘤样变和 5 7例浸润性宫颈癌中的表达情况 ,并以 11例宫颈鳞状上皮作对照。结果　P53蛋白在慢性宫颈炎中的阳性表达 ( 3 7 5 % )与对照组( 0 0 % )间有明显差异 (P <0 0 5 ) ;P53蛋白在慢性宫颈炎中的表达率 ( 3 7 5 % )与在浸润性宫颈癌中的表达率 ( 78 9% )之间有显著性差异 (P <0 0 5 ) ;P53蛋白在宫颈上皮内瘤样变中的表达率 ( 60 0 % )与对照组间差异显著 (P <0 0 1;)P53蛋白在宫颈癌中的表达率 ( 78 9% )与对照组间差异显著 (P <0 0 1) ;P53蛋白在宫颈上皮内瘤样变中的表达与在宫颈侵润癌中的表达间无显著性差异 (P >0 0 5 ) ;P53蛋白在宫颈浸润癌病理Ⅱ级和Ⅲ级中的表达率明显高于病理Ⅰ级 (P <0 0 5 ) ,P53蛋白在宫颈癌结节型中的表达( 94 1% )明显高于溃疡型 ( 3 3 1% ) (P <0 0 5 )。结论　P53蛋白的过度表达与宫颈癌的发生有关 ,是宫颈癌发生的早期事件 ;P53蛋白在慢性宫颈炎中的表达与细胞的增殖率高有关 :P53蛋白在宫颈浸润癌中的表达与宫颈癌细胞的分化程度有关 ,并且与宫颈癌的大体病理分型有关。Objective In order to discover how P 53 would express in the following groups, whether the rate of P 53 positive expression might show any correlation with established grade, clinical stage and gross type in invasive cervical cancer Methods The expression of P 53 protein in 11 cases of normal squmous cell epithelia, 8 cases of cervicitis, 10 cases of CIN and 57 cases of invasive cervical carcinoma were examined immunohistochemically Results The results indicated that there was a significant difference between cervictitis (37 5%) and control group (0) ( P <0 05); The difference between cervicitis (37 5%) and invasive cervical cancer (78 9%) was significant ( P <0 05); There was a remarkably difference between either CIN (60 0%) and control ( P <0 01) or cervical carcinoma(78 9%) and control group ( P <0 01); The P 53 positive rate of cervical cancer in grade Ⅱ and grade Ⅲ was much more higher than that of in grade Ⅰ( P <0 05); The P 53 positive rate in nodular type (94 1%) was significantly higher than that of in ulcerating type (33 1%) ( P <0 05) Conclusion ①Overexpression of P 53 protein is associated with the cervical carcinogenesis ②P 53 immunoreactivity is not only in neoplastic but also in inflammatory lesions of the uterine cervix; ③ The positive rate of P 53 protein is associated with the degree of differentiation of cervical carcinoma cells ④ The positive rate of P 53 protein is correlated with the gross type of cervical carcinoma

关 键 词：宫颈癌 宫颈上皮内瘤样变 宫颈炎 P53蛋白 免疫组织化学 

分 类 号：R737.33[医药卫生—肿瘤] R711.32[医药卫生—临床医学]