急性脑梗死患者血清及脑脊液中抗心磷脂抗体的临床意义  

The Clinical Significance of Contents of Anticardiolipin Antibodies in Cerebrospinal Fluid and Serum of Patients with Acute Cerebral Infarction

作　　者：陈月琴[1] 孙金旭[1] 周桂桂[1] 

机构地区：[1]南京医科大学附属脑科医院检验科,210029

出　　处：《皖南医学院学报》2001年第4期270-271,共2页Journal of Wannan Medical College

摘　　要：目的　探讨急性脑梗死患者血清及脑脊液中抗心磷脂抗体 (AnticardiolipinAntibodies ,ACA)的变化及临床意义。方法　应用酶联免疫吸附法对 42例急性脑梗死患者进行血清及脑脊液中ACA含量的测定 ,并与对照组比较。结果　急性脑梗死患者血清ACA的IgG阳性率为 35 .7% ,脑脊液ACA的IgG阳性率为 31.0 % ,显著高于对照组 (P <0 .0 5 )。结论　提示ACA对脑梗死的发生 ,病情的复发有一定影响 ,脑脊液中ACA阳性率的检出是疾病严重程度的表示。Objective To investigate the varied contents of anticardiolipin antibodies (ACA) in CSF and the relation to the contents in serum in acute cerebral infarction (ACI). Methods Using ELISA, ACA were measured in serum and CSF from 42 patients with ACI and 30 controls. Results The positive rate of ACA-IgG in the serum ACI patients' was 35.7%, the positive rate of ACA-IgG in CSF was 31.0% , much higher than that in controls (P<0.05). Conclusion The findings suggest that ACA may fluence the occurrence and recurrence of cerebral infarction to some extent, and the positive rate of ACA in CSF is indicative of the severity of ACI. =

关 键 词：急性脑梗死 血清 脑脊液 抗心磷脂抗体 酶联免疫吸附法 测定 

分 类 号：R743.33[医药卫生—神经病学与精神病学] R446.62[医药卫生—临床医学]