脑肽精对阿尔茨海默病模型大鼠的治疗作用  

Remedial effects of brain peptide crystal on model rats with Alzheimer's disease

作　　者：安玉会[1] 郭茂峰[1] 孟庆瑞[1] 张维娟[1] 李怀洲[1] 王志超[1] 章萍[1] 

机构地区：[1]郑州大学基础医学院生物化学与分子生物学教研室,郑州450052

出　　处：《郑州大学学报（医学版）》2003年第6期884-886,共3页Journal of Zhengzhou University(Medical Sciences)

基　　金：河南省杰出人才创新基金资助项目 0 2 10 0 0 5 0 0

摘　　要：目的 :观察脑肽精 (BPC)对阿尔茨海默病 (AD)大鼠学习记忆力的影响。方法 :雄性SD大鼠 84只 ,随机分成 7组 ,每组 1 2只。Ⅰ组为正常对照组 ,Ⅱ组为AD模型组 ,Ⅲ组为AD模型 +生理盐水组 ,Ⅳ组为AD模型 +脑复康 0 .3g/kg治疗组 ,Ⅴ组为AD模型 +BPC 1 5mg/kg治疗组 ,Ⅵ组为AD模型 +BPC 30mg/kg治疗组 ,Ⅶ组为AD模型 +BPC 6 0mg/kg治疗组。采用大鼠脑组织立体定位微量注射技术 ,用鹅膏蕈氨酸 (IBO)损毁大鼠双侧迈纳特基底核 (nbM)。手术后BPC连续灌胃 2 0d ,1次 /d ,每次 2ml。灌胃期满后即做迷宫实验及跳台实验以测学习、记忆能力。结果 :①与正常对照组比较 ,模型组的学习记忆能力均显著下降 (P <0 .0 1 ) ;②与模型组比较 ,生理盐水组无明显改变 (P >0 .0 5 ) ;③与模型组比较 ,脑复康组及BPC各浓度组的学习记忆能力均显著升高 (P <0 .0 1 )。结论Aim:To observe the remedial effects of brain peptide crystal (BPC) on the animal model of non-hereditary Alzheimer's disease (AD). Methods: Eighty-four healthy male SD rats (8～12 weeks, 170～210 g) were randomly divided into 7 groups and each group contained 12 rats. The AD animal model was established by injecting IBO 1 μl (5 μg) into rats brain to damage bilateral nbM in rat brain. Group Ⅰ was normal group, group Ⅱ was AD animal model, group Ⅲ, Ⅳ,Ⅴ,Ⅵ and Ⅶ were AD animal model orally normal saline, Naofukang (0.3 g/kg·d), BPC (15 mg/kg·d), BPC (30 mg/kg·d), BPC (60 mg/kg·d), respectively. Group Ⅰ and group Ⅱ had not been treated. The experiment lasted for 20 days, the drugs were given once per day, and 2 ml for each time. The learning and remembering ability was tested by Y-maze test and jumping table experiment.Results: The learning and remembering ability of AD models decreased significantly( P <0.01).Comparing with group Ⅱ: the learning and remembering ability of group Ⅲ did not change significantly. Comparing with group Ⅱ: the learning and remembering ability of naofukang group and BPC groups increased significantly( P <0.01).Conclusion:PBC has good remedial effects on Aizheimer's disease.

关 键 词：脑肽精 阿尔茨海默病 大鼠 学习 记忆能力 

分 类 号：R362[医药卫生—病理学]